node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACN83194.1 | comFC | BHWA1_00700 | BHWA1_01804 | HepA, Superfamily II D/R helicase, SNF2 family. | ComFC, Predicted amidophosphoribosyltransferase. | 0.867 |
ACN83194.1 | dnaN | BHWA1_00700 | BHWA1_01258 | HepA, Superfamily II D/R helicase, SNF2 family. | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | 0.951 |
ACN83194.1 | polA | BHWA1_00700 | BHWA1_02587 | HepA, Superfamily II D/R helicase, SNF2 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.992 |
ACN83194.1 | recA | BHWA1_00700 | BHWA1_01107 | HepA, Superfamily II D/R helicase, SNF2 family. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.933 |
ACN83194.1 | rpoB | BHWA1_00700 | BHWA1_02325 | HepA, Superfamily II D/R helicase, SNF2 family. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.950 |
ACN83194.1 | sbcD | BHWA1_00700 | BHWA1_00716 | HepA, Superfamily II D/R helicase, SNF2 family. | Putative exonuclease. | 0.702 |
ACN83194.1 | topA | BHWA1_00700 | BHWA1_02590 | HepA, Superfamily II D/R helicase, SNF2 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.825 |
comFC | ACN83194.1 | BHWA1_01804 | BHWA1_00700 | ComFC, Predicted amidophosphoribosyltransferase. | HepA, Superfamily II D/R helicase, SNF2 family. | 0.867 |
comFC | dnaN | BHWA1_01804 | BHWA1_01258 | ComFC, Predicted amidophosphoribosyltransferase. | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | 0.846 |
comFC | lexA | BHWA1_01804 | BHWA1_00626 | ComFC, Predicted amidophosphoribosyltransferase. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.457 |
comFC | polA | BHWA1_01804 | BHWA1_02587 | ComFC, Predicted amidophosphoribosyltransferase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.998 |
comFC | recA | BHWA1_01804 | BHWA1_01107 | ComFC, Predicted amidophosphoribosyltransferase. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.963 |
comFC | recX | BHWA1_01804 | BHWA1_01873 | ComFC, Predicted amidophosphoribosyltransferase. | Recombination regulator RecX. | 0.474 |
comFC | sbcD | BHWA1_01804 | BHWA1_00716 | ComFC, Predicted amidophosphoribosyltransferase. | Putative exonuclease. | 0.974 |
comFC | topA | BHWA1_01804 | BHWA1_02590 | ComFC, Predicted amidophosphoribosyltransferase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.996 |
dnaN | ACN83194.1 | BHWA1_01258 | BHWA1_00700 | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | HepA, Superfamily II D/R helicase, SNF2 family. | 0.951 |
dnaN | comFC | BHWA1_01258 | BHWA1_01804 | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | ComFC, Predicted amidophosphoribosyltransferase. | 0.846 |
dnaN | lexA | BHWA1_01258 | BHWA1_00626 | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.408 |
dnaN | polA | BHWA1_01258 | BHWA1_02587 | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.998 |
dnaN | recA | BHWA1_01258 | BHWA1_01107 | DNA polymerase III beta (beta clamp) subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for i [...] | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.860 |