LMJF_32_0460 protein (Leishmania major) - STRING interaction network

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LMJF_32_0460

Putative prostaglandin f synthase. (279 aa)

Predicted Functional Partners:

LMJF_14_1480

0.904

P100/11E

0.902

GSH1

0.728

LMJF_36_4170

0.662

LMJF_16_0760

0.468

LMJF_24_2060

0.440

LMJF_36_6310

0.418

LMJF_07_0090

0.418

LMJF_33_0520

0.401

DHFR-TS

0.400

Your Current Organism:

Leishmania major

NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHFR-TS	GSH1	P07382	Q4QDM2	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Putative gamma-glutamylcysteine synthetase.	0.489
DHFR-TS	LMJF_07_0090	P07382	Q4QIT5	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.971
DHFR-TS	LMJF_24_2060	P07382	Q4QAC4	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.545
DHFR-TS	LMJF_32_0460	P07382	Q4Q5N9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Putative prostaglandin f synthase.	0.400
DHFR-TS	LMJF_36_4170	P07382	Q4Q0Z7	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Putative oxidoreductase.	0.614
DHFR-TS	LMJF_36_6310	P07382	Q4Q0C9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	Putative homocysteine S-methyltransferase.	0.673
DHFR-TS	P100/11E	P07382	P22045	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.	0.400
GSH1	DHFR-TS	Q4QDM2	P07382	Putative gamma-glutamylcysteine synthetase.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	0.489
GSH1	LMJF_32_0460	Q4QDM2	Q4Q5N9	Putative gamma-glutamylcysteine synthetase.	Putative prostaglandin f synthase.	0.728
GSH1	P100/11E	Q4QDM2	P22045	Putative gamma-glutamylcysteine synthetase.	9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.	0.728
LMJF_07_0090	DHFR-TS	Q4QIT5	P07382	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.	0.971
LMJF_07_0090	LMJF_32_0460	Q4QIT5	Q4Q5N9	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Putative prostaglandin f synthase.	0.418
LMJF_07_0090	LMJF_36_6310	Q4QIT5	Q4Q0C9	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Putative homocysteine S-methyltransferase.	0.926
LMJF_07_0090	P100/11E	Q4QIT5	P22045	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.	0.418
LMJF_14_1480	LMJF_32_0460	Q4QFI5	Q4Q5N9	Putative glutathione-S-transferase/glutaredoxin.	Putative prostaglandin f synthase.	0.904
LMJF_14_1480	P100/11E	Q4QFI5	P22045	Putative glutathione-S-transferase/glutaredoxin.	9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.	0.904
LMJF_16_0760	LMJF_24_2060	Q4QEU3	Q4QAC4	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.998
LMJF_16_0760	LMJF_32_0460	Q4QEU3	Q4Q5N9	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	Putative prostaglandin f synthase.	0.468
LMJF_16_0760	LMJF_33_0520	Q4QEU3	Q4Q4F7	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	Putative d-xylulose reductase.	0.598
LMJF_16_0760	LMJF_36_4170	Q4QEU3	Q4Q0Z7	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	Putative oxidoreductase.	0.544