STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LMJF_32_0460Putative prostaglandin f synthase. (279 aa)    
Predicted Functional Partners:
LMJF_14_1480
Putative glutathione-S-transferase/glutaredoxin.
     
 0.904
P100/11E
9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.
  
  
 
0.902
GSH1
Putative gamma-glutamylcysteine synthetase.
   
 0.728
LMJF_36_4170
Putative oxidoreductase.
  
 
 0.662
LMJF_16_0760
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
  
 
 0.468
LMJF_24_2060
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.440
LMJF_36_6310
Putative homocysteine S-methyltransferase.
   
 0.418
LMJF_07_0090
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
 0.418
LMJF_33_0520
Putative d-xylulose reductase.
  
 
 0.401
DHFR-TS
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.
  
  
 0.400
Your Current Organism:
Leishmania major
NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major
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