node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHFR-TS | GSH1 | P07382 | Q4QDM2 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative gamma-glutamylcysteine synthetase. | 0.489 |
DHFR-TS | LMJF_07_0090 | P07382 | Q4QIT5 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
DHFR-TS | LMJF_24_2060 | P07382 | Q4QAC4 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.545 |
DHFR-TS | LMJF_32_0460 | P07382 | Q4Q5N9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative prostaglandin f synthase. | 0.400 |
DHFR-TS | LMJF_36_4170 | P07382 | Q4Q0Z7 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative oxidoreductase. | 0.614 |
DHFR-TS | LMJF_36_6310 | P07382 | Q4Q0C9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative homocysteine S-methyltransferase. | 0.673 |
DHFR-TS | P100/11E | P07382 | P22045 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | 9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde. | 0.400 |
GSH1 | DHFR-TS | Q4QDM2 | P07382 | Putative gamma-glutamylcysteine synthetase. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | 0.489 |
GSH1 | LMJF_32_0460 | Q4QDM2 | Q4Q5N9 | Putative gamma-glutamylcysteine synthetase. | Putative prostaglandin f synthase. | 0.728 |
GSH1 | P100/11E | Q4QDM2 | P22045 | Putative gamma-glutamylcysteine synthetase. | 9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde. | 0.728 |
LMJF_07_0090 | DHFR-TS | Q4QIT5 | P07382 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | 0.971 |
LMJF_07_0090 | LMJF_32_0460 | Q4QIT5 | Q4Q5N9 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative prostaglandin f synthase. | 0.418 |
LMJF_07_0090 | LMJF_36_6310 | Q4QIT5 | Q4Q0C9 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative homocysteine S-methyltransferase. | 0.926 |
LMJF_07_0090 | P100/11E | Q4QIT5 | P22045 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde. | 0.418 |
LMJF_14_1480 | LMJF_32_0460 | Q4QFI5 | Q4Q5N9 | Putative glutathione-S-transferase/glutaredoxin. | Putative prostaglandin f synthase. | 0.904 |
LMJF_14_1480 | P100/11E | Q4QFI5 | P22045 | Putative glutathione-S-transferase/glutaredoxin. | 9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde. | 0.904 |
LMJF_16_0760 | LMJF_24_2060 | Q4QEU3 | Q4QAC4 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.998 |
LMJF_16_0760 | LMJF_32_0460 | Q4QEU3 | Q4Q5N9 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Putative prostaglandin f synthase. | 0.468 |
LMJF_16_0760 | LMJF_33_0520 | Q4QEU3 | Q4Q4F7 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Putative d-xylulose reductase. | 0.598 |
LMJF_16_0760 | LMJF_36_4170 | Q4QEU3 | Q4Q0Z7 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Putative oxidoreductase. | 0.544 |