node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHFR-TS | FTHS | P07382 | Q4Q735 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Formate--tetrahydrofolate ligase. | 0.965 |
DHFR-TS | GCVH | P07382 | E9AFU9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.665 |
DHFR-TS | GCVL-1 | P07382 | E9AE44 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative dihydrolipoamide dehydrogenase. | 0.410 |
DHFR-TS | GCVP | P07382 | Q4Q9I8 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.750 |
DHFR-TS | GCVT-2 | P07382 | Q4Q134 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.962 |
DHFR-TS | GCVT1 | P07382 | Q4Q135 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.962 |
DHFR-TS | LMJF_31_2650 | P07382 | Q4Q5Z6 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Acetoin dehydrogenase e3 component-like protein. | 0.410 |
DHFR-TS | LMJF_36_6390 | P07382 | Q4Q0B9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Putative methylenetetrahydrofolate reductase. | 0.960 |
DHFR-TS | SHMT-L | P07382 | Q4Q828 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.986 |
FTHS | DHFR-TS | Q4Q735 | P07382 | Formate--tetrahydrofolate ligase. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | 0.965 |
FTHS | GCVH | Q4Q735 | E9AFU9 | Formate--tetrahydrofolate ligase. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.678 |
FTHS | GCVP | Q4Q735 | Q4Q9I8 | Formate--tetrahydrofolate ligase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.718 |
FTHS | GCVT-2 | Q4Q735 | Q4Q134 | Formate--tetrahydrofolate ligase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.960 |
FTHS | GCVT1 | Q4Q735 | Q4Q135 | Formate--tetrahydrofolate ligase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.960 |
FTHS | LMJF_36_6390 | Q4Q735 | Q4Q0B9 | Formate--tetrahydrofolate ligase. | Putative methylenetetrahydrofolate reductase. | 0.959 |
FTHS | SHMT-L | Q4Q735 | Q4Q828 | Formate--tetrahydrofolate ligase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.972 |
GCVH | DHFR-TS | E9AFU9 | P07382 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family. | 0.665 |
GCVH | FTHS | E9AFU9 | Q4Q735 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Formate--tetrahydrofolate ligase. | 0.678 |
GCVH | GCVL-1 | E9AFU9 | E9AE44 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Putative dihydrolipoamide dehydrogenase. | 0.967 |
GCVH | GCVP | E9AFU9 | Q4Q9I8 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |