STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POLIBPutative mitochondrial DNA polymerase I protein B. (1429 aa)    
Predicted Functional Partners:
POLIA
Putative mitochondrial DNA polymerase I protein A.
     
 
0.900
PRI1
Putative mitochondrial DNA primase.
      
 0.810
UMSBP2
Universal minicircle sequence binding protein.
     
 0.651
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 
 0.542
LMJF_23_1270
Uncharacterized protein.
  
 
 0.516
LMJF_27_1890
Putative endo/exonuclease Mre11.
  
 0.514
LMJF_07_1140
Putative methionine-S-sulfoxide reductase.
  
  
 0.470
LMJF_28_0530
RAD50 DNA repair-like protein.
  
 
 0.465
LMJF_14_0260
VWFA domain-containing protein.
   
 
 0.415
Your Current Organism:
Leishmania major
NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major
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