STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GLO1Trypanothione-dependent glyoxalase I. (141 aa)    
Predicted Functional Partners:
LMJF_12_0220
Putative hydroxyacylglutathione hydrolase.
  
 
 0.985
P100/11E
9,11-endoperoxide prostaglandin H2 reductase; Catalyzes the NADP-dependent formation of prostaglandin F2- alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p- nitrobenzaldehyde.
  
 
 0.639
LMJF_30_0610
Putative nitrate reductase.
  
  
 0.624
LMJF_35_1540
Putative reiske iron-sulfur protein.
  
  
 0.534
LMJF_28_1010
Putative ribosomal protein S20.
   
  
 0.519
LMJF_27_0050
RNA helicase.
  
 
 0.508
DHFR-TS
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family.
  
  
 0.502
LMJF_07_1140
Putative methionine-S-sulfoxide reductase.
  
  
 0.499
idi1
Isopentenyl-pyrophosphate isomerase.
  
  
 0.497
LMJF_01_0200
LMWPc domain-containing protein.
  
  
 0.450
Your Current Organism:
Leishmania major
NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.