Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
EED33398.1Fatty acyl-CoA hydrolase, medium chain (Thioesterase B); [I] COG0657 Esterase/lipase; Belongs to the type-B carboxylesterase/lipase family. (592 aa)    
Predicted Functional Partners:
icd_2
Isocitrate dehydrogenase, NADP-dependent; [C] COG0538 Isocitrate dehydrogenases.
 
     0.829
EED33026.1
Peptidase M28; [R] COG2234 Predicted aminopeptidases.
 
  0.690
EED33331.1
Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.
    
 0.656
EED31850.1
Peptidase M28; [R] COG2234 Predicted aminopeptidases.
  
  0.646
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
     
  0.596
EED31511.1
[O] COG0386 Glutathione peroxidase; Belongs to the glutathione peroxidase family.
     
 0.560
hepA
RNA polymerase-associated protein HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
    
  0.546
EED31275.1
Putative helicase; [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family.
    
  0.546
EED32250.1
Type III restriction enzyme, res subunit family; [LKJ] COG0513 Superfamily II DNA and RNA helicases.
    
  0.546
gmk
Guanylate kinase; [P] COG3709 Uncharacterized component of phosphonate metabolism.
  
 
  0.544
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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