| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EED32115.1 | EED33251.1 | NOR53_3577 | NOR53_1283 | Putative glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.406 |
| EED32115.1 | birA | NOR53_3577 | NOR53_168 | Putative glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.451 |
| EED32833.1 | EED33251.1 | NOR53_1074 | NOR53_1283 | [V] COG0842 ABC-type multidrug transport system, permease component. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.630 |
| EED33251.1 | EED32115.1 | NOR53_1283 | NOR53_3577 | Oxidoreductase; [C] COG0778 Nitroreductase. | Putative glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | 0.406 |
| EED33251.1 | EED32833.1 | NOR53_1283 | NOR53_1074 | Oxidoreductase; [C] COG0778 Nitroreductase. | [V] COG0842 ABC-type multidrug transport system, permease component. | 0.630 |
| EED33251.1 | NOR53_280 | NOR53_1283 | NOR53_280 | Oxidoreductase; [C] COG0778 Nitroreductase. | [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 0.413 |
| EED33251.1 | NOR53_854 | NOR53_1283 | NOR53_854 | Oxidoreductase; [C] COG0778 Nitroreductase. | Glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | 0.408 |
| EED33251.1 | birA | NOR53_1283 | NOR53_168 | Oxidoreductase; [C] COG0778 Nitroreductase. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.628 |
| EED33251.1 | cysG | NOR53_1283 | NOR53_2213 | Oxidoreductase; [C] COG0778 Nitroreductase. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.660 |
| EED33251.1 | purE | NOR53_1283 | NOR53_1848 | Oxidoreductase; [C] COG0778 Nitroreductase. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.534 |
| EED33251.1 | purK | NOR53_1283 | NOR53_2114 | Oxidoreductase; [C] COG0778 Nitroreductase. | Phosphoribosylaminoimidazole carboxylase atpase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.530 |
| NOR53_280 | EED33251.1 | NOR53_280 | NOR53_1283 | [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.413 |
| NOR53_854 | EED33251.1 | NOR53_854 | NOR53_1283 | Glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.408 |
| NOR53_854 | birA | NOR53_854 | NOR53_168 | Glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.451 |
| birA | EED32115.1 | NOR53_168 | NOR53_3577 | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | 0.451 |
| birA | EED33251.1 | NOR53_168 | NOR53_1283 | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.628 |
| birA | NOR53_854 | NOR53_168 | NOR53_854 | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Glyoxalase/bleomycin resistance protein/dioxygenase; [E] COG0346 Lactoylglutathione lyase and related lyases. | 0.451 |
| birA | cysG | NOR53_168 | NOR53_2213 | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.740 |
| cysG | EED33251.1 | NOR53_2213 | NOR53_1283 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Oxidoreductase; [C] COG0778 Nitroreductase. | 0.660 |
| cysG | birA | NOR53_2213 | NOR53_168 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.740 |