Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EED32426.1[H] COG0720 6-pyruvoyl-tetrahydropterin synthase. (165 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
 
 0.939
EED32834.1
NADPH-dependent 7-cyano-7-deazaguanine reductase (nadph-dependent nitrile oxidoreductase); [R] COG0780 Enzyme related to GTP cyclohydrolase I.
  
  
 0.901
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.881
NOR53_851
Short-chain dehydrogenase/reductase SDR; [V] COG0842 ABC-type multidrug transport system, permease component.
 
  
  0.819
EED32424.1
Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
 
   
 0.660
queD
Queuosine biosynthesis protein QueD; [H] COG0720 6-pyruvoyl-tetrahydropterin synthase.
    
  0.650
EED31774.1
[P] COG1785 Alkaline phosphatase; Belongs to the alkaline phosphatase family.
     
  0.647
EED31835.1
Putative sodium/proline symporter; [S] COG3924 Predicted membrane protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
     0.634
EED33300.1
[P] COG3540 Phosphodiesterase/alkaline phosphatase D.
     
  0.627
folE_2
[H] COG0302 GTP cyclohydrolase I.
  
 
 0.597
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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