STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
birAbiotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (319 aa)    
Predicted Functional Partners:
coaX
Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
  
    0.971
NOR53_213
methylcrotonoyl-CoA carboxylase subunit alpha; [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase).
 
  
 0.966
accC
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.962
NOR53_898
Peptidase M22, glycoprotease; [O] COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone.
 
    0.960
EED31654.1
Acetyl-/propionyl-coenzyme A carboxylase alpha chain; [I] COG0439 Biotin carboxylase.
 
  
 0.938
oadA
Oxaloacetate decarboxylase alpha subunit; [I] COG0511 Biotin carboxyl carrier protein.
 
 
 0.914
EED32676.1
Putative methylmalonyl-CoA decarboxylasealpha-subunit; [I] COG0825 Acetyl-CoA carboxylase alpha subunit.
 
 0.906
cdd
[FJ] COG0590 Cytosine/adenosine deaminases.
  
    0.876
tadA
tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
    0.876
NOR53_294
methylcrotonoyl-CoA carboxylase beta chain; [I] COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).
  
 
 0.865
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.