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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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second shell of interactors
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filled nodes:
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aceKIsocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (583 aa)    
Predicted Functional Partners:
icd_1
Isocitrate dehydrogenase, NADP-dependent; [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase.
 
 
 
 0.940
EED32618.1
[C] COG2224 Isocitrate lyase.
  
  
 0.936
NOR53_364
Phosphoglycerate mutase; [G] COG0406 Fructose-2,6-bisphosphatase.
       0.799
NOR53_384
Phosphoglycerate mutase family protein; [G] COG0406 Fructose-2,6-bisphosphatase.
       0.795
NOR53_177
Oxidoreductase, short chain dehydrogenase/reductase family; [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.710
icd_2
Isocitrate dehydrogenase, NADP-dependent; [C] COG0538 Isocitrate dehydrogenases.
   
 
 0.638
NOR53_291
[I] COG1960 Acyl-CoA dehydrogenases.
       0.530
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
 
  
 0.514
NOR53_272
[I] COG1960 Acyl-CoA dehydrogenases.
       0.471
EED33826.1
Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
 
     0.428
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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