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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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EED33256.1Thiamine pyrophosphate enzyme domain protein TPP-binding protein; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (519 aa)    
Predicted Functional Partners:
ilvN
[E] COG0440 Acetolactate synthase, small (regulatory) subunit.
 
 0.961
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
 
 0.908
ilvD
[EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.807
EED33454.1
Putative Phosphate acetyl/butyryl transferase subfamily; [C] COG0281 Malic enzyme.
  
 0.794
EED31663.1
2-oxoacid-ferredoxin oxidoreductase beta chain; [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit.
  
 
 0.733
EED33520.1
Putative threonine dehydratase biosynthetic; [E] COG0498 Threonine synthase.
  
 0.729
ilvA
Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 0.729
EED31664.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; [C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits.
  
 
 0.690
NOR53_953
Oxidoreductase; [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.631
EED31698.1
Tartrate dehydrogenase; [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase.
 
 0.622
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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