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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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Score
EED33826.1Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. (162 aa)    
Predicted Functional Partners:
EED33827.1
[I] COG1960 Acyl-CoA dehydrogenases.
       0.773
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
 
    0.604
EED33828.1
Transcriptional regulator, LysR family; [K] COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
 
     0.595
ligK_1
4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase; [H] COG0684 Demethylmenaquinone methyltransferase.
  
   
 0.592
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.530
ligK_2
4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase; [H] COG0684 Demethylmenaquinone methyltransferase.
  
   
 0.510
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
  
 0.495
iscR
Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
      
 0.473
cafA
Hypothetical protein; [J] COG1530 Ribonucleases G and E; ibonuclease G.
      
 0.472
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
     0.428
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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