| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folA | folB | NOR53_3673 | NOR53_476 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.621 |
| folA | folC | NOR53_3673 | NOR53_1911 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | 0.918 |
| folA | folK_1 | NOR53_3673 | NOR53_2432 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.597 |
| folA | folP | NOR53_3673 | NOR53_2427 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | [H] COG0294 Dihydropteroate synthase and related enzymes. | 0.754 |
| folB | folA | NOR53_476 | NOR53_3673 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.621 |
| folB | folC | NOR53_476 | NOR53_1911 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | 0.895 |
| folB | folE_1 | NOR53_476 | NOR53_2163 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | [H] COG0302 GTP cyclohydrolase I. | 0.930 |
| folB | folE_2 | NOR53_476 | NOR53_1545 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | [H] COG0302 GTP cyclohydrolase I. | 0.941 |
| folB | folK_1 | NOR53_476 | NOR53_2432 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.990 |
| folB | folK_2 | NOR53_476 | NOR53_586 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.996 |
| folB | folP | NOR53_476 | NOR53_2427 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | [H] COG0294 Dihydropteroate synthase and related enzymes. | 0.989 |
| folB | ftsH | NOR53_476 | NOR53_2522 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.577 |
| folB | pabC | NOR53_476 | NOR53_1969 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Aminodeoxychorismate lyase; [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.471 |
| folC | folA | NOR53_1911 | NOR53_3673 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.918 |
| folC | folB | NOR53_1911 | NOR53_476 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.895 |
| folC | folE_1 | NOR53_1911 | NOR53_2163 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | [H] COG0302 GTP cyclohydrolase I. | 0.615 |
| folC | folE_2 | NOR53_1911 | NOR53_1545 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | [H] COG0302 GTP cyclohydrolase I. | 0.560 |
| folC | folK_1 | NOR53_1911 | NOR53_2432 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.876 |
| folC | folK_2 | NOR53_1911 | NOR53_586 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.746 |
| folC | folP | NOR53_1911 | NOR53_2427 | [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the folylpolyglutamate synthase family. | [H] COG0294 Dihydropteroate synthase and related enzymes. | 0.996 |