Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dacAD-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5; [M] COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (379 aa)    
Predicted Functional Partners:
mrdA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
 
 
 0.920
ftsI
Peptidoglycan synthetase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.
  
 
 0.829
mrcB
Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
   
 
 0.809
NOR53_750
[M] COG2951 Membrane-bound lytic murein transglycosylase B.
 
 
 0.775
EED32218.1
[M] COG0768 Cell division protein FtsI/penicillin-binding protein 2.
     
 0.736
amiB
[M] COG0860 N-acetylmuramoyl-L-alanine amidase.
   
 
 0.709
mrdB
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
   
 0.700
EED31514.1
[S] COG2921 Uncharacterized conserved protein; Belongs to the UPF0250 family.
  
    0.682
rlpA
Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
  
  
 0.672
EED33824.1
N-acetyl-anhydromuramyl-L-alanine amidase AmpD; [V] COG3023 Negative regulator of beta-lactamase expression.
  
  
 0.663
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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