Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
EED32047.1DnaJ-domain containing protein; [O] COG2214 DnaJ-class molecular chaperone. (263 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.958
yhgI
IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.939
NOR53_192
Hypothetical protein.
  
 0.916
EED31647.1
ATPase; [S] COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family.
  
 
 0.798
erpA
HesB/YadR/YfhF; Required for insertion of 4Fe-4S clusters for at least IspG.
  
 
 0.798
EED32603.1
Cysteine desulfurase; [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes.
  
 0.761
dndA
Cysteine desulfurase DndA; [E] COG0520 Selenocysteine lyase.
  
 0.761
EED32046.1
[M] COG1560 Lauroyl/myristoyl acyltransferase.
       0.680
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
   
 
 0.646
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
   
 0.615
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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