Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EED31837.1[E] COG2939 Carboxypeptidase C (cathepsin A). (496 aa)    
Predicted Functional Partners:
EED31627.1
Putative calcium binding signal peptide protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.
    
  0.675
hepA
RNA polymerase-associated protein HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
    
  0.586
EED31275.1
Putative helicase; [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family.
    
  0.586
EED32250.1
Type III restriction enzyme, res subunit family; [LKJ] COG0513 Superfamily II DNA and RNA helicases.
    
  0.586
icd_1
Isocitrate dehydrogenase, NADP-dependent; [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase.
   
 
  0.553
icd_2
Isocitrate dehydrogenase, NADP-dependent; [C] COG0538 Isocitrate dehydrogenases.
   
 
  0.553
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
     
  0.538
EED31730.1
Metallophosphoesterase; [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases.
     
  0.538
EED31276.1
Nuclease sbcCD subunit C; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.
     
  0.521
dndD
DNA sulfur modification protein DndD; [L] COG0419 ATPase involved in DNA repair.
     
  0.521
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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