Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
iscRIron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (160 aa)    
Predicted Functional Partners:
EED32603.1
Cysteine desulfurase; [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes.
  
 
 0.936
dndA
Cysteine desulfurase DndA; [E] COG0520 Selenocysteine lyase.
  
 
 0.936
EED31647.1
ATPase; [S] COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family.
  
  
 0.906
yhgI
IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
  
 0.785
sufB
FeS assembly protein SufB; [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
     
 0.780
sufC
FeS assembly ATPase SufC; [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase.
     
 0.705
sufD
FeS assembly protein SufD; [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
     
 0.699
sufT
Probable FeS assembly SUF system protein SufT; [D] COG0489 ATPases involved in chromosome partitioning.
     
 0.637
EED32850.1
Reductive dehalogenase; [C] COG1600 Uncharacterized Fe-S protein.
  
  
 0.622
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 0.606
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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