Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
spoT_1Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (457 aa)    
Predicted Functional Partners:
spoT_2
Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase; [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; overlaps another CDS with the same product name.
     0.994
EED31684.1
Sensor protein GacS; [T] COG0642 Signal transduction histidine kinase.
 
  
 0.869
EED33682.1
[T] COG0642 Signal transduction histidine kinase.
 
  
 0.861
NOR53_215
[T] COG0642 Signal transduction histidine kinase.
    
 0.844
rplJ
[J] COG0244 Ribosomal protein L10.
  
   0.834
rpsF
Na+/solute symporter; Binds together with S18 to 16S ribosomal RNA.
  
 
 
 0.826
rpsM
Ribosomal protein S13p/S18e; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.
   
  0.825
rplU
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
 
   0.813
rplS
Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
 
 
   0.812
rplX
Ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
  
   0.807
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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