STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
add_2Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (346 aa)    
Predicted Functional Partners:
EED32530.1
[F] COG1957 Inosine-uridine nucleoside N-ribohydrolase; Belongs to the IUNH family.
 
     0.823
NOR53_18
Hypothetical protein; [R] COG1073 Hydrolases of the alpha/beta superfamily.
    
 0.715
NOR53_716
[GEPR] COG0477 Permeases of the major facilitator superfamily.
       0.689
NOR53_390
HAD-superfamily hydrolase subfamily IA, variant 3; [R] COG0637 Predicted phosphatase/phosphohexomutase.
     
 0.677
EED32894.1
Cytosolic 5'-nucleotidase 1A; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.
     
  0.667
EED32529.1
[F] COG5042 Purine nucleoside permease.
 
     0.646
EED32528.1
[F] COG1816 Adenosine deaminase.
 
    
0.590
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.545
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.519
xdhB
Xanthine dehydrogenase, molybdopterin binding subunit; [C] COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs.
 
  
 0.493
Your Current Organism:
gamma proteobacterium NOR53
NCBI taxonomy Id: 566466
Other names: g. proteobacterium NOR5-3, gamma proteobacterium NOR5-3
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