STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LINJ_13_0050Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (268 aa)    
Predicted Functional Partners:
RNHii
Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
     
 
0.900
LINJ.12.0667
Uncharacterized protein.
   
 
 0.886
LINJ_15_1500
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.805
DHFR-TS
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
  
 
 0.778
LINJ_22_0270
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
  
  
 0.718
LINJ_32_3120
DNA helicase; Belongs to the MCM family.
   
  
 0.630
LINJ_03_0080
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.
   
  
 0.601
LINJ_24_0930
DNA helicase; Belongs to the MCM family.
   
    0.573
LINJ_28_0030
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
  
 0.556
LINJ_06_0290
Putative ribonuclease H1.
  
 
 0.537
Your Current Organism:
Leishmania infantum
NCBI taxonomy Id: 5671
Other names: L. infantum, Leishmania (Leishmania) infantum, Leishmania donovani infantum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.