STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LINJ_15_0010Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)    
Predicted Functional Partners:
LINJ_35_2900
Uncharacterized protein.
    
 
 0.961
LINJ_30_1370
Uncharacterized protein.
    
 0.945
LINJ_17_0330
Histone H2A; Belongs to the histone H2A family.
 
 
 0.914
LINJ_21_1160
Histone H2A; Belongs to the histone H2A family.
   
 0.907
LINJ_21_1170
Histone H2A; Belongs to the histone H2A family.
   
 0.907
LINJ_19_0630
Putative histone H3 variant.
 
 
 0.865
LINJ_10_0920
Histone H3.
 
 
 0.864
LINJ_16_0600
Putative histone H3.
 
 
 0.864
LINJ_10_1050
Histone H3.
   
 0.855
LINJ_28_0030
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
 0.837
Your Current Organism:
Leishmania infantum
NCBI taxonomy Id: 5671
Other names: L. infantum, Leishmania (Leishmania) infantum, Leishmania donovani infantum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.