LOC109975375 protein (Labrus bergylta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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[Homology]

Score

LOC109975375

E2F_CC-MB domain-containing protein. (224 aa)

Predicted Functional Partners:

rb1

0.977

LOC109998711

0.958

LOC109995121

0.945

LOC109975820

0.945

rbl1

0.931

ENSLBEP00000016731

0.931

LOC109998245

0.907

ccna1

0.907

LOC109985571

0.896

e2f4

0.888

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000016731	LOC109975375	ENSLBEP00000016731	ENSLBEP00000000200	Uncharacterized protein.	E2F_CC-MB domain-containing protein.	0.931
ENSLBEP00000016731	LOC109975820	ENSLBEP00000016731	ENSLBEP00000016040	Uncharacterized protein.	Uncharacterized protein.	0.974
ENSLBEP00000016731	LOC109985571	ENSLBEP00000016731	ENSLBEP00000021656	Uncharacterized protein.	E2F transcription factor 1.	0.955
ENSLBEP00000016731	LOC109995121	ENSLBEP00000016731	ENSLBEP00000002398	Uncharacterized protein.	Transcription factor.	0.974
ENSLBEP00000016731	LOC109998245	ENSLBEP00000016731	ENSLBEP00000021164	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.881
ENSLBEP00000016731	LOC109998711	ENSLBEP00000016731	ENSLBEP00000009870	Uncharacterized protein.	Retinoblastoma-like 2 (p130).	0.846
ENSLBEP00000016731	ccna1	ENSLBEP00000016731	ENSLBEP00000027557	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.881
ENSLBEP00000016731	e2f4	ENSLBEP00000016731	ENSLBEP00000000188	Uncharacterized protein.	E2F_TDP domain-containing protein.	0.979
ENSLBEP00000016731	rb1	ENSLBEP00000016731	ENSLBEP00000035832	Uncharacterized protein.	Retinoblastoma 1.	0.875
LOC109975375	ENSLBEP00000016731	ENSLBEP00000000200	ENSLBEP00000016731	E2F_CC-MB domain-containing protein.	Uncharacterized protein.	0.931
LOC109975375	LOC109975820	ENSLBEP00000000200	ENSLBEP00000016040	E2F_CC-MB domain-containing protein.	Uncharacterized protein.	0.945
LOC109975375	LOC109985571	ENSLBEP00000000200	ENSLBEP00000021656	E2F_CC-MB domain-containing protein.	E2F transcription factor 1.	0.896
LOC109975375	LOC109995121	ENSLBEP00000000200	ENSLBEP00000002398	E2F_CC-MB domain-containing protein.	Transcription factor.	0.945
LOC109975375	LOC109998245	ENSLBEP00000000200	ENSLBEP00000021164	E2F_CC-MB domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.907
LOC109975375	LOC109998711	ENSLBEP00000000200	ENSLBEP00000009870	E2F_CC-MB domain-containing protein.	Retinoblastoma-like 2 (p130).	0.958
LOC109975375	ccna1	ENSLBEP00000000200	ENSLBEP00000027557	E2F_CC-MB domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.907
LOC109975375	e2f4	ENSLBEP00000000200	ENSLBEP00000000188	E2F_CC-MB domain-containing protein.	E2F_TDP domain-containing protein.	0.888
LOC109975375	rb1	ENSLBEP00000000200	ENSLBEP00000035832	E2F_CC-MB domain-containing protein.	Retinoblastoma 1.	0.977
LOC109975375	rbl1	ENSLBEP00000000200	ENSLBEP00000008296	E2F_CC-MB domain-containing protein.	Retinoblastoma-like 1 (p107).	0.931
LOC109975820	ENSLBEP00000016731	ENSLBEP00000016040	ENSLBEP00000016731	Uncharacterized protein.	Uncharacterized protein.	0.974

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.728

expected number of edges:

13

PPI enrichment p-value:

0.00398

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006811

Ion transport

7 of 67

1.54

2.24

3.35e-07

GO:0055072

Iron ion homeostasis

2 of 5

2.12

0.93

0.0180

GO:0098662

Inorganic cation transmembrane transport

3 of 33

1.48

0.84

0.0160

GO:0065007

Biological regulation

8 of 482

0.74

0.55

0.0039

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046915

Transition metal ion transmembrane transporter activity

3 of 8

2.1

1.57

0.00093

GO:0046914

Transition metal ion binding

6 of 87

1.36

1.48

5.35e-05

GO:0015093

Ferrous iron transmembrane transporter activity

2 of 2

2.52

1.21

0.0060

GO:0046872

Metal ion binding

7 of 381

0.79

0.57

0.0060

GO:0043167

Ion binding

9 of 779

0.58

0.43

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2881

Mixed, incl. Ferrous iron transporter FeoA domain, and Phosphoglycerate mutase family

4 of 12

2.04

2.07

6.66e-05

CL:6577

Mixed, incl. Iron transport, and Ferrous iron transporter FeoA domain

2 of 6

2.04

0.71

0.0483

CL:2883

Ferrous iron transporter FeoA domain, and Iron transport

2 of 5

2.12

0.71

0.0483

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0410

Iron transport

2 of 2

2.52

1.12

0.0089

KW-0408

Iron

3 of 45

1.35

0.7

0.0292

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07670

Nucleoside recognition

3 of 3

2.52

2.0

0.00019

PF07664

Ferrous iron transport protein B C terminus

3 of 3

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030389

FeoB-type guanine nucleotide-binding (G) domain

3 of 3

2.52

1.8

0.00046

IPR011642

Nucleoside transporter/FeoB GTPase, Gate domain

3 of 3

2.52

1.8

0.00046

IPR011640

Ferrous iron transport protein B, C-terminal

3 of 3

2.52

1.8

0.00046

IPR038157

Ferrous iron transporter, core domain

3 of 4

2.4

1.78

0.00046

IPR007167

Ferrous iron transporter FeoA domain

3 of 4

2.4

1.78

0.00046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00899

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria. This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble ...

3 of 4

2.4

2.19

7.40e-05

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