ENSLBEP00000006922 protein (Labrus bergylta)

Nodes:

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSLBEP00000006922

Bravo_FIGEY domain-containing protein. (80 aa)

Predicted Functional Partners:

cntn2

0.825

LOC109996330

0.802

CNTN1

0.802

cntnap1

0.797

cntn5

0.768

LOC109983188

0.768

LOC109983172

0.768

LOC109982864

0.768

LOC109982872

0.768

LOC109994901

0.751

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTN1	ENSLBEP00000006922	ENSLBEP00000009958	ENSLBEP00000006922	Contactin 1.	Bravo_FIGEY domain-containing protein.	0.802
CNTN1	LOC109994901	ENSLBEP00000009958	ENSLBEP00000025580	Contactin 1.	Protein tyrosine phosphatase receptor type Ga.	0.764
CNTN1	cntnap1	ENSLBEP00000009958	ENSLBEP00000030188	Contactin 1.	Contactin associated protein 1.	0.897
ENSLBEP00000006922	CNTN1	ENSLBEP00000006922	ENSLBEP00000009958	Bravo_FIGEY domain-containing protein.	Contactin 1.	0.802
ENSLBEP00000006922	LOC109982864	ENSLBEP00000006922	ENSLBEP00000029811	Bravo_FIGEY domain-containing protein.	Contactin 3a, tandem duplicate 2.	0.768
ENSLBEP00000006922	LOC109982872	ENSLBEP00000006922	ENSLBEP00000030239	Bravo_FIGEY domain-containing protein.	Contactin 3a, tandem duplicate 1.	0.768
ENSLBEP00000006922	LOC109983172	ENSLBEP00000006922	ENSLBEP00000013875	Bravo_FIGEY domain-containing protein.	Contactin 3b.	0.768
ENSLBEP00000006922	LOC109983188	ENSLBEP00000006922	ENSLBEP00000013514	Bravo_FIGEY domain-containing protein.	Contactin 4.	0.768
ENSLBEP00000006922	LOC109994901	ENSLBEP00000006922	ENSLBEP00000025580	Bravo_FIGEY domain-containing protein.	Protein tyrosine phosphatase receptor type Ga.	0.751
ENSLBEP00000006922	LOC109996330	ENSLBEP00000006922	ENSLBEP00000005740	Bravo_FIGEY domain-containing protein.	Contactin 1b.	0.802
ENSLBEP00000006922	cntn2	ENSLBEP00000006922	ENSLBEP00000008051	Bravo_FIGEY domain-containing protein.	Contactin 2.	0.825
ENSLBEP00000006922	cntn5	ENSLBEP00000006922	ENSLBEP00000000395	Bravo_FIGEY domain-containing protein.	Contactin 5.	0.768
ENSLBEP00000006922	cntnap1	ENSLBEP00000006922	ENSLBEP00000030188	Bravo_FIGEY domain-containing protein.	Contactin associated protein 1.	0.797
LOC109982864	ENSLBEP00000006922	ENSLBEP00000029811	ENSLBEP00000006922	Contactin 3a, tandem duplicate 2.	Bravo_FIGEY domain-containing protein.	0.768
LOC109982864	LOC109994901	ENSLBEP00000029811	ENSLBEP00000025580	Contactin 3a, tandem duplicate 2.	Protein tyrosine phosphatase receptor type Ga.	0.764
LOC109982864	cntnap1	ENSLBEP00000029811	ENSLBEP00000030188	Contactin 3a, tandem duplicate 2.	Contactin associated protein 1.	0.656
LOC109982872	ENSLBEP00000006922	ENSLBEP00000030239	ENSLBEP00000006922	Contactin 3a, tandem duplicate 1.	Bravo_FIGEY domain-containing protein.	0.768
LOC109982872	LOC109994901	ENSLBEP00000030239	ENSLBEP00000025580	Contactin 3a, tandem duplicate 1.	Protein tyrosine phosphatase receptor type Ga.	0.764
LOC109982872	cntnap1	ENSLBEP00000030239	ENSLBEP00000030188	Contactin 3a, tandem duplicate 1.	Contactin associated protein 1.	0.656
LOC109983172	ENSLBEP00000006922	ENSLBEP00000013875	ENSLBEP00000006922	Contactin 3b.	Bravo_FIGEY domain-containing protein.	0.768

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

20

PPI enrichment p-value:

8.9e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 23

2.29

3.8

2.05e-08

GO:0006364

rRNA processing

10 of 205

1.64

3.59

3.74e-13

GO:0042254

Ribosome biogenesis

11 of 267

1.57

3.44

2.58e-14

GO:0042273

Ribosomal large subunit biogenesis

6 of 64

1.92

3.32

1.82e-08

GO:0000466

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 47

1.98

2.93

3.83e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 537

1.13

1.22

1.78e-05

GO:0043021

Ribonucleoprotein complex binding

3 of 39

1.84

1.13

0.0059

GO:0070180

Large ribosomal subunit rRNA binding

2 of 8

2.35

0.93

0.0193

GO:0005488

Binding

11 of 4312

0.36

0.26

0.0342

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

7 of 30

2.32

5.68

7.77e-13

GO:0030684

Preribosome

8 of 89

1.91

4.38

2.91e-12

GO:0005730

Nucleolus

10 of 232

1.59

3.35

5.86e-13

GO:1990904

Ribonucleoprotein complex

10 of 436

1.31

2.16

7.08e-11

GO:0005732

sno(s)RNA-containing ribonucleoprotein complex

2 of 24

1.87

0.92

0.0169

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4359

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

7 of 30

2.32

5.55

1.64e-12

CL:4363

Preribosome, large subunit precursor, and Ribosomal protein L10

6 of 19

2.45

5.44

1.02e-11

CL:4368

Preribosome, large subunit precursor

4 of 5

2.86

4.26

1.24e-08

CL:4188

Nucleolus

9 of 149

1.73

3.84

1.72e-12

CL:4177

Ribosome biogenesis, and tRNA modification

10 of 198

1.66

3.68

2.64e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

4 of 93

1.59

1.47

0.00041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 132

1.61

2.15

2.74e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 136

1.6

2.13

2.74e-06

MAP-72312

rRNA processing

6 of 141

1.58

2.1

2.74e-06

MAP-8953854

Metabolism of RNA

8 of 553

1.11

1.28

3.44e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

5 of 120

1.57

1.85

2.10e-05

GOCC:0031981

Nuclear lumen

9 of 510

1.2

1.58

1.38e-07

GOCC:0005732

Small nucleolar ribonucleoprotein complex

2 of 21

1.93

0.87

0.0217

GOCC:0005634

Nucleus

10 of 1299

0.84

0.85

3.04e-06

GOCC:1990904

Ribonucleoprotein complex

5 of 415

1.03

0.74

0.0061

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 19

2.15

1.77

0.00037

KW-0690

Ribosome biogenesis

3 of 21

2.11

1.76

0.00037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 4

2.65

0.73

0.0482

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 4

2.65

0.73

0.0482

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