ENSLBEP00000007029 protein (Labrus bergylta)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSLBEP00000007029

Uncharacterized protein. (261 aa)

Predicted Functional Partners:

UNC79

0.884

ak9

0.871

LOC109989387

0.738

RIMS2

0.675

ENSLBEP00000031587

0.675

ENSLBEP00000031622

0.675

rbbp5

0.644

ash2l

0.633

LOC109983404

0.604

ENSLBEP00000006652

0.578

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000006652	ENSLBEP00000007029	ENSLBEP00000006652	ENSLBEP00000007029	TROVE domain-containing protein.	Uncharacterized protein.	0.578
ENSLBEP00000006652	LOC109983404	ENSLBEP00000006652	ENSLBEP00000035910	TROVE domain-containing protein.	Im:7152348.	0.455
ENSLBEP00000006652	LOC109989387	ENSLBEP00000006652	ENSLBEP00000037487	TROVE domain-containing protein.	RAN binding protein 2.	0.985
ENSLBEP00000006652	ak9	ENSLBEP00000006652	ENSLBEP00000027171	TROVE domain-containing protein.	Adenylate kinase 9.	0.484
ENSLBEP00000006652	rbbp5	ENSLBEP00000006652	ENSLBEP00000035000	TROVE domain-containing protein.	Retinoblastoma binding protein 5.	0.734
ENSLBEP00000007029	ENSLBEP00000006652	ENSLBEP00000007029	ENSLBEP00000006652	Uncharacterized protein.	TROVE domain-containing protein.	0.578
ENSLBEP00000007029	ENSLBEP00000031587	ENSLBEP00000007029	ENSLBEP00000031587	Uncharacterized protein.	C2 domain-containing protein.	0.675
ENSLBEP00000007029	ENSLBEP00000031622	ENSLBEP00000007029	ENSLBEP00000031622	Uncharacterized protein.	PDZ domain-containing protein.	0.675
ENSLBEP00000007029	LOC109983404	ENSLBEP00000007029	ENSLBEP00000035910	Uncharacterized protein.	Im:7152348.	0.604
ENSLBEP00000007029	LOC109989387	ENSLBEP00000007029	ENSLBEP00000037487	Uncharacterized protein.	RAN binding protein 2.	0.738
ENSLBEP00000007029	RIMS2	ENSLBEP00000007029	ENSLBEP00000002860	Uncharacterized protein.	Regulating synaptic membrane exocytosis 2.	0.675
ENSLBEP00000007029	UNC79	ENSLBEP00000007029	ENSLBEP00000027854	Uncharacterized protein.	Unc-79 homolog, NALCN channel complex subunit.	0.884
ENSLBEP00000007029	ak9	ENSLBEP00000007029	ENSLBEP00000027171	Uncharacterized protein.	Adenylate kinase 9.	0.871
ENSLBEP00000007029	ash2l	ENSLBEP00000007029	ENSLBEP00000037230	Uncharacterized protein.	Ash2 like, histone lysine methyltransferase complex subunit.	0.633
ENSLBEP00000007029	rbbp5	ENSLBEP00000007029	ENSLBEP00000035000	Uncharacterized protein.	Retinoblastoma binding protein 5.	0.644
ENSLBEP00000031587	ENSLBEP00000007029	ENSLBEP00000031587	ENSLBEP00000007029	C2 domain-containing protein.	Uncharacterized protein.	0.675
ENSLBEP00000031587	ENSLBEP00000031622	ENSLBEP00000031587	ENSLBEP00000031622	C2 domain-containing protein.	PDZ domain-containing protein.	0.987
ENSLBEP00000031587	RIMS2	ENSLBEP00000031587	ENSLBEP00000002860	C2 domain-containing protein.	Regulating synaptic membrane exocytosis 2.	0.888
ENSLBEP00000031587	UNC79	ENSLBEP00000031587	ENSLBEP00000027854	C2 domain-containing protein.	Unc-79 homolog, NALCN channel complex subunit.	0.755
ENSLBEP00000031622	ENSLBEP00000007029	ENSLBEP00000031622	ENSLBEP00000007029	PDZ domain-containing protein.	Uncharacterized protein.	0.675

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.863

expected number of edges:

12

PPI enrichment p-value:

0.000464

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033108

Mitochondrial respiratory chain complex assembly

7 of 47

1.95

3.64

2.62e-09

GO:0033617

Mitochondrial cytochrome c oxidase assembly

5 of 29

2.01

2.69

2.00e-06

GO:0007005

Mitochondrion organization

9 of 274

1.29

1.84

5.45e-08

GO:0065003

Protein-containing complex assembly

8 of 488

0.99

0.95

0.00011

GO:0016043

Cellular component organization

10 of 1889

0.5

0.35

0.0153

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005507

Copper ion binding

4 of 22

2.04

1.91

0.00015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

9 of 69

1.89

4.65

1.55e-13

GO:0005740

Mitochondrial envelope

10 of 466

1.11

1.46

1.23e-08

GO:0005743

Mitochondrial inner membrane

5 of 269

1.05

0.78

0.0042

GO:0031966

Mitochondrial membrane

6 of 422

0.93

0.72

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33498264

(2021) Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

6 of 16

2.35

3.81

2.66e-08

PMID:18761382

(2009) Redox regulation of protein folding in the mitochondrial intermembrane space.

6 of 34

2.02

2.89

6.77e-07

PMID:28886682

(2017) Copper Acquisition and Utilization in Fungi.

6 of 36

2.0

2.86

6.77e-07

PMID:34557489

(2021) Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

6 of 47

1.88

2.56

2.01e-06

PMID:29495437

(2018) The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants.

5 of 25

2.08

2.44

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2974

Respiratory chain complex IV assembly, and Heme a metabolic process

9 of 18

2.48

8.1

5.75e-18

CL:2995

Mixed, incl. CHCH domain, and Cytochrome c oxidase biogenesis protein Cmc1 like

4 of 6

2.6

3.49

2.57e-07

CL:2977

Copper chaperone activity, and Cytochrome oxidase c subunit VIb

3 of 5

2.56

2.32

4.72e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 59

1.91

4.21

1.45e-11

GOCC:1902695

Metallochaperone complex

3 of 4

2.65

2.52

2.12e-05

GOCC:0005740

Mitochondrial envelope

9 of 368

1.17

1.52

1.20e-07

GOCC:0005739

Mitochondrion

10 of 851

0.85

0.87

2.70e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

8 of 97

1.69

3.31

1.73e-10

KW-0186

Copper

4 of 27

1.95

2.29

1.50e-05

KW-0496

Mitochondrion

10 of 807

0.87

0.91

1.36e-06

KW-0999

Mitochondrion inner membrane

4 of 213

1.05

0.6

0.0273

KW-0143

Chaperone

3 of 105

1.23

0.6

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08583

Cytochrome c oxidase biogenesis protein Cmc1 like

2 of 2

2.78

1.06

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013892

Cytochrome c oxidase biogenesis protein Cmc1-like

2 of 2

2.78

0.78

0.0390

IPR009069

Cysteine alpha-hairpin motif superfamily

2 of 3

2.6

0.78

0.0390

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