sec22a protein (Labrus bergylta) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

sec22a

SEC22 homolog A, vesicle trafficking protein; Belongs to the synaptobrevin family. (303 aa)

Predicted Functional Partners:

stx5

0.989

gosr2

0.986

bet1

0.986

stx18

0.982

LOC109985293

0.980

ykt6

0.975

BET1L

0.970

use1

0.970

rint1

0.946

LOC109986713

0.938

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BET1L	LOC109986713	ENSLBEP00000006296	ENSLBEP00000014736	Bet1 golgi vesicular membrane trafficking protein like.	SEC24 homolog B, COPII coat complex component.	0.838
BET1L	gosr2	ENSLBEP00000006296	ENSLBEP00000030870	Bet1 golgi vesicular membrane trafficking protein like.	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.993
BET1L	sec22a	ENSLBEP00000006296	ENSLBEP00000009549	Bet1 golgi vesicular membrane trafficking protein like.	SEC22 homolog A, vesicle trafficking protein; Belongs to the synaptobrevin family.	0.970
BET1L	stx18	ENSLBEP00000006296	ENSLBEP00000037009	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 18.	0.807
BET1L	stx5	ENSLBEP00000006296	ENSLBEP00000008692	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 5A; Belongs to the syntaxin family.	0.997
BET1L	use1	ENSLBEP00000006296	ENSLBEP00000007172	Bet1 golgi vesicular membrane trafficking protein like.	Unconventional SNARE in the ER 1 homolog (S. cerevisiae).	0.920
BET1L	ykt6	ENSLBEP00000006296	ENSLBEP00000031836	Bet1 golgi vesicular membrane trafficking protein like.	YKT6 v-SNARE homolog (S. cerevisiae); Belongs to the synaptobrevin family.	0.996
LOC109985293	bet1	ENSLBEP00000001402	ENSLBEP00000031040	BCL2 interacting protein 1b.	Bet1 golgi vesicular membrane trafficking protein.	0.663
LOC109985293	gosr2	ENSLBEP00000001402	ENSLBEP00000030870	BCL2 interacting protein 1b.	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.571
LOC109985293	rint1	ENSLBEP00000001402	ENSLBEP00000038382	BCL2 interacting protein 1b.	RAD50 interactor 1.	0.996
LOC109985293	sec22a	ENSLBEP00000001402	ENSLBEP00000009549	BCL2 interacting protein 1b.	SEC22 homolog A, vesicle trafficking protein; Belongs to the synaptobrevin family.	0.980
LOC109985293	stx18	ENSLBEP00000001402	ENSLBEP00000037009	BCL2 interacting protein 1b.	Syntaxin 18.	0.989
LOC109985293	stx5	ENSLBEP00000001402	ENSLBEP00000008692	BCL2 interacting protein 1b.	Syntaxin 5A; Belongs to the syntaxin family.	0.667
LOC109985293	use1	ENSLBEP00000001402	ENSLBEP00000007172	BCL2 interacting protein 1b.	Unconventional SNARE in the ER 1 homolog (S. cerevisiae).	0.999
LOC109985293	ykt6	ENSLBEP00000001402	ENSLBEP00000031836	BCL2 interacting protein 1b.	YKT6 v-SNARE homolog (S. cerevisiae); Belongs to the synaptobrevin family.	0.823
LOC109986713	BET1L	ENSLBEP00000014736	ENSLBEP00000006296	SEC24 homolog B, COPII coat complex component.	Bet1 golgi vesicular membrane trafficking protein like.	0.838
LOC109986713	bet1	ENSLBEP00000014736	ENSLBEP00000031040	SEC24 homolog B, COPII coat complex component.	Bet1 golgi vesicular membrane trafficking protein.	0.918
LOC109986713	gosr2	ENSLBEP00000014736	ENSLBEP00000030870	SEC24 homolog B, COPII coat complex component.	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.811
LOC109986713	sec22a	ENSLBEP00000014736	ENSLBEP00000009549	SEC24 homolog B, COPII coat complex component.	SEC22 homolog A, vesicle trafficking protein; Belongs to the synaptobrevin family.	0.938
LOC109986713	stx5	ENSLBEP00000014736	ENSLBEP00000008692	SEC24 homolog B, COPII coat complex component.	Syntaxin 5A; Belongs to the syntaxin family.	0.857

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

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