slc43a1 protein (Labrus bergylta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

slc43a1

Solute carrier family 43 member 1a. (559 aa)

Predicted Functional Partners:

tnn

0.434

ENSLBEP00000001163

0.413

ENSLBEP00000012652

0.413

tnr

0.413

tnc

0.413

ENSLBEP00000035454

0.413

ENSLBEP00000035471

0.413

LOC109979877

0.413

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000001163	ENSLBEP00000012652	ENSLBEP00000001163	ENSLBEP00000012652	Tenascin C.	Fibrinogen C-terminal domain-containing protein.	0.710
ENSLBEP00000001163	ENSLBEP00000035454	ENSLBEP00000001163	ENSLBEP00000035454	Tenascin C.	Uncharacterized protein.	0.710
ENSLBEP00000001163	ENSLBEP00000035471	ENSLBEP00000001163	ENSLBEP00000035471	Tenascin C.	Uncharacterized protein.	0.824
ENSLBEP00000001163	LOC109979877	ENSLBEP00000001163	ENSLBEP00000038856	Tenascin C.	Uncharacterized protein.	0.712
ENSLBEP00000001163	slc43a1	ENSLBEP00000001163	ENSLBEP00000012963	Tenascin C.	Solute carrier family 43 member 1a.	0.413
ENSLBEP00000001163	tnc	ENSLBEP00000001163	ENSLBEP00000031036	Tenascin C.	Zmp:0000000846.	0.714
ENSLBEP00000001163	tnn	ENSLBEP00000001163	ENSLBEP00000023121	Tenascin C.	Tenascin N.	0.816
ENSLBEP00000001163	tnr	ENSLBEP00000001163	ENSLBEP00000023357	Tenascin C.	Tenascin R (restrictin, janusin).	0.824
ENSLBEP00000012652	ENSLBEP00000001163	ENSLBEP00000012652	ENSLBEP00000001163	Fibrinogen C-terminal domain-containing protein.	Tenascin C.	0.710
ENSLBEP00000012652	ENSLBEP00000035454	ENSLBEP00000012652	ENSLBEP00000035454	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.969
ENSLBEP00000012652	ENSLBEP00000035471	ENSLBEP00000012652	ENSLBEP00000035471	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.962
ENSLBEP00000012652	LOC109979877	ENSLBEP00000012652	ENSLBEP00000038856	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.969
ENSLBEP00000012652	slc43a1	ENSLBEP00000012652	ENSLBEP00000012963	Fibrinogen C-terminal domain-containing protein.	Solute carrier family 43 member 1a.	0.413
ENSLBEP00000012652	tnc	ENSLBEP00000012652	ENSLBEP00000031036	Fibrinogen C-terminal domain-containing protein.	Zmp:0000000846.	0.710
ENSLBEP00000012652	tnn	ENSLBEP00000012652	ENSLBEP00000023121	Fibrinogen C-terminal domain-containing protein.	Tenascin N.	0.816
ENSLBEP00000012652	tnr	ENSLBEP00000012652	ENSLBEP00000023357	Fibrinogen C-terminal domain-containing protein.	Tenascin R (restrictin, janusin).	0.824
ENSLBEP00000035454	ENSLBEP00000001163	ENSLBEP00000035454	ENSLBEP00000001163	Uncharacterized protein.	Tenascin C.	0.710
ENSLBEP00000035454	ENSLBEP00000012652	ENSLBEP00000035454	ENSLBEP00000012652	Uncharacterized protein.	Fibrinogen C-terminal domain-containing protein.	0.969
ENSLBEP00000035454	ENSLBEP00000035471	ENSLBEP00000035454	ENSLBEP00000035471	Uncharacterized protein.	Uncharacterized protein.	0.716
ENSLBEP00000035454	LOC109979877	ENSLBEP00000035454	ENSLBEP00000038856	Uncharacterized protein.	Uncharacterized protein.	0.712

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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