LOC109977874 protein (Labrus bergylta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC109977874

Uncharacterized protein. (441 aa)

Predicted Functional Partners:

ubb

0.478

rps27a

0.473

LOC110000550

0.448

uba52

0.434

LOC109992891

0.429

LOC109988571

0.429

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC109977874	LOC109988571	ENSLBEP00000018347	ENSLBEP00000037485	Uncharacterized protein.	Growth arrest specific 7.	0.429
LOC109977874	LOC109992891	ENSLBEP00000018347	ENSLBEP00000006773	Uncharacterized protein.	Growth arrest-specific 7a.	0.429
LOC109977874	LOC110000550	ENSLBEP00000018347	ENSLBEP00000013464	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.448
LOC109977874	rps27a	ENSLBEP00000018347	ENSLBEP00000000668	Uncharacterized protein.	Ribosomal protein S27a.	0.473
LOC109977874	uba52	ENSLBEP00000018347	ENSLBEP00000037051	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.434
LOC109977874	ubb	ENSLBEP00000018347	ENSLBEP00000021236	Uncharacterized protein.	Ubiquitin B.	0.478
LOC109988571	LOC109977874	ENSLBEP00000037485	ENSLBEP00000018347	Growth arrest specific 7.	Uncharacterized protein.	0.429
LOC109988571	LOC110000550	ENSLBEP00000037485	ENSLBEP00000013464	Growth arrest specific 7.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.456
LOC109988571	rps27a	ENSLBEP00000037485	ENSLBEP00000000668	Growth arrest specific 7.	Ribosomal protein S27a.	0.881
LOC109988571	uba52	ENSLBEP00000037485	ENSLBEP00000037051	Growth arrest specific 7.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.854
LOC109988571	ubb	ENSLBEP00000037485	ENSLBEP00000021236	Growth arrest specific 7.	Ubiquitin B.	0.860
LOC109992891	LOC109977874	ENSLBEP00000006773	ENSLBEP00000018347	Growth arrest-specific 7a.	Uncharacterized protein.	0.429
LOC109992891	LOC110000550	ENSLBEP00000006773	ENSLBEP00000013464	Growth arrest-specific 7a.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.456
LOC109992891	rps27a	ENSLBEP00000006773	ENSLBEP00000000668	Growth arrest-specific 7a.	Ribosomal protein S27a.	0.881
LOC109992891	uba52	ENSLBEP00000006773	ENSLBEP00000037051	Growth arrest-specific 7a.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.854
LOC109992891	ubb	ENSLBEP00000006773	ENSLBEP00000021236	Growth arrest-specific 7a.	Ubiquitin B.	0.860
LOC110000550	LOC109977874	ENSLBEP00000013464	ENSLBEP00000018347	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.448
LOC110000550	LOC109988571	ENSLBEP00000013464	ENSLBEP00000037485	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Growth arrest specific 7.	0.456
LOC110000550	LOC109992891	ENSLBEP00000013464	ENSLBEP00000006773	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Growth arrest-specific 7a.	0.456
LOC110000550	rps27a	ENSLBEP00000013464	ENSLBEP00000000668	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ribosomal protein S27a.	0.987

page 1 of 2

Network Stats

number of nodes:

5

number of edges:

6

average node degree:

2.4

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.214

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About