ENSLBEP00000025395 protein (Labrus bergylta)

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white nodes:
second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSLBEP00000025395

annotation not available (72 aa)

Predicted Functional Partners:

LOC109981860

0.679

sgcb

0.672

sgce

0.640

LOC109980963

0.615

ENSLBEP00000020769

0.615

LOC110003829

0.615

ENSLBEP00000018985

0.605

LOC110002113

0.605

ENSLBEP00000037803

0.543

sgcg

0.534

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000018985	ENSLBEP00000020769	ENSLBEP00000018985	ENSLBEP00000020769	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.563
ENSLBEP00000018985	ENSLBEP00000025395	ENSLBEP00000018985	ENSLBEP00000025395	Uncharacterized protein.	annotation not available	0.605
ENSLBEP00000018985	ENSLBEP00000037803	ENSLBEP00000018985	ENSLBEP00000037803	Uncharacterized protein.	Uncharacterized protein.	0.673
ENSLBEP00000018985	LOC109980963	ENSLBEP00000018985	ENSLBEP00000014650	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.563
ENSLBEP00000018985	LOC109981860	ENSLBEP00000018985	ENSLBEP00000037363	Uncharacterized protein.	Sarcoglycan, alpha.	0.651
ENSLBEP00000018985	LOC110003829	ENSLBEP00000018985	ENSLBEP00000022470	Uncharacterized protein.	Dystroglycan 1.	0.563
ENSLBEP00000018985	sgcb	ENSLBEP00000018985	ENSLBEP00000038041	Uncharacterized protein.	Sarcoglycan, beta (dystrophin-associated glycoprotein).	0.542
ENSLBEP00000018985	sgce	ENSLBEP00000018985	ENSLBEP00000030795	Uncharacterized protein.	Sarcoglycan, epsilon.	0.608
ENSLBEP00000018985	sgcg	ENSLBEP00000018985	ENSLBEP00000016900	Uncharacterized protein.	Sarcoglycan, gamma.	0.673
ENSLBEP00000020769	ENSLBEP00000018985	ENSLBEP00000020769	ENSLBEP00000018985	Peptidase S72 domain-containing protein.	Uncharacterized protein.	0.563
ENSLBEP00000020769	ENSLBEP00000025395	ENSLBEP00000020769	ENSLBEP00000025395	Peptidase S72 domain-containing protein.	annotation not available	0.615
ENSLBEP00000020769	ENSLBEP00000037803	ENSLBEP00000020769	ENSLBEP00000037803	Peptidase S72 domain-containing protein.	Uncharacterized protein.	0.657
ENSLBEP00000020769	LOC109980963	ENSLBEP00000020769	ENSLBEP00000014650	Peptidase S72 domain-containing protein.	Peptidase S72 domain-containing protein.	0.891
ENSLBEP00000020769	LOC109981860	ENSLBEP00000020769	ENSLBEP00000037363	Peptidase S72 domain-containing protein.	Sarcoglycan, alpha.	0.643
ENSLBEP00000020769	LOC110002113	ENSLBEP00000020769	ENSLBEP00000038181	Peptidase S72 domain-containing protein.	Sarcospan (Kras oncogene-associated gene).	0.563
ENSLBEP00000020769	sgcb	ENSLBEP00000020769	ENSLBEP00000038041	Peptidase S72 domain-containing protein.	Sarcoglycan, beta (dystrophin-associated glycoprotein).	0.586
ENSLBEP00000020769	sgce	ENSLBEP00000020769	ENSLBEP00000030795	Peptidase S72 domain-containing protein.	Sarcoglycan, epsilon.	0.643
ENSLBEP00000020769	sgcg	ENSLBEP00000020769	ENSLBEP00000016900	Peptidase S72 domain-containing protein.	Sarcoglycan, gamma.	0.657
ENSLBEP00000025395	ENSLBEP00000018985	ENSLBEP00000025395	ENSLBEP00000018985	annotation not available	Uncharacterized protein.	0.605
ENSLBEP00000025395	ENSLBEP00000020769	ENSLBEP00000025395	ENSLBEP00000020769	annotation not available	Peptidase S72 domain-containing protein.	0.615

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.907

expected number of edges:

10

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030042

Actin filament depolymerization

3 of 11

2.71

1.91

0.00032

GO:0051014

Actin filament severing

3 of 16

2.55

1.85

0.00038

GO:0030043

Actin filament fragmentation

2 of 3

3.1

1.37

0.0034

GO:0030036

Actin cytoskeleton organization

6 of 512

1.35

1.27

0.00038

GO:0022604

Regulation of cell morphogenesis

4 of 196

1.59

1.14

0.0034

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003779

Actin binding

5 of 498

1.28

0.85

0.0087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

5 of 376

1.4

1.19

0.0011

GO:0005925

Focal adhesion

3 of 112

1.7

0.97

0.0109

GO:0005856

Cytoskeleton

7 of 1877

0.85

0.6

0.0073

GO:0043232

Intracellular non-membrane-bounded organelle

8 of 3620

0.62

0.4

0.0212

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2568

ADF/Cofilin, and Sema3A PAK dependent Axon repulsion

3 of 6

2.98

2.42

4.03e-05

CL:2418

Mixed, incl. Dual specificity phosphatase, catalytic domain, and MAP kinase activity

4 of 89

1.93

1.83

0.00018

CL:1933

Parvin, and Integrin-linked protein kinase, pseudokinase domain

2 of 7

2.73

1.2

0.0067

CL:1398

Mixed, incl. Phenylalanine zipper, and Insulin receptor, trans-membrane domain

2 of 8

2.67

1.18

0.0071

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446388

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

3 of 11

2.71

2.27

6.62e-05

MAP-9020591

Interleukin-12 signaling

3 of 15

2.58

2.23

7.41e-05

MAP-447115

Interleukin-12 family signaling

3 of 21

2.43

2.09

0.00012

MAP-399954

Sema3A PAK dependent Axon repulsion

3 of 26

2.34

1.99

0.00017

MAP-446353

Cell-extracellular matrix interactions

3 of 32

2.25

1.89

0.00024

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 120

1.67

0.97

0.0106

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017904

ADF/Cofilin

3 of 3

3.28

2.67

1.53e-05

IPR002108

Actin-depolymerising factor homology domain

3 of 12

2.67

2.05

0.00017

IPR029006

ADF-H/Gelsolin-like domain superfamily

3 of 30

2.28

1.52

0.0014

IPR028433

Parvin

2 of 3

3.1

1.31

0.0044

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00102

Actin depolymerisation factor/cofilin -like domains

3 of 11

2.71

2.45

3.06e-05

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