LOC109995533 protein (Labrus bergylta) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

LOC109995533

Myotubularin 1. (607 aa)

Predicted Functional Partners:

pik3c3

0.877

FIG4

0.877

cdipt

0.854

LOC109995351

0.853

pikfyve

0.853

LOC109993643

0.849

impad1

0.849

LOC109984194

0.847

ENSLBEP00000023422

0.847

pip4p1

0.844

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000023422	FIG4	ENSLBEP00000023422	ENSLBEP00000026979	Inositol polyphosphate-4-phosphatase type II B.	FIG4 phosphoinositide 5-phosphatase.	0.847
ENSLBEP00000023422	LOC109984194	ENSLBEP00000023422	ENSLBEP00000006625	Inositol polyphosphate-4-phosphatase type II B.	Inositol polyphosphate-4-phosphatase type I Ab.	0.843
ENSLBEP00000023422	LOC109995533	ENSLBEP00000023422	ENSLBEP00000026709	Inositol polyphosphate-4-phosphatase type II B.	Myotubularin 1.	0.847
ENSLBEP00000023422	impad1	ENSLBEP00000023422	ENSLBEP00000027010	Inositol polyphosphate-4-phosphatase type II B.	Inositol monophosphatase domain containing 1.	0.840
ENSLBEP00000023422	pik3c3	ENSLBEP00000023422	ENSLBEP00000000163	Inositol polyphosphate-4-phosphatase type II B.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.854
ENSLBEP00000023422	pikfyve	ENSLBEP00000023422	ENSLBEP00000029703	Inositol polyphosphate-4-phosphatase type II B.	Phosphoinositide kinase, FYVE finger containing.	0.847
FIG4	ENSLBEP00000023422	ENSLBEP00000026979	ENSLBEP00000023422	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type II B.	0.847
FIG4	LOC109984194	ENSLBEP00000026979	ENSLBEP00000006625	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type I Ab.	0.847
FIG4	LOC109995533	ENSLBEP00000026979	ENSLBEP00000026709	FIG4 phosphoinositide 5-phosphatase.	Myotubularin 1.	0.877
FIG4	pik3c3	ENSLBEP00000026979	ENSLBEP00000000163	FIG4 phosphoinositide 5-phosphatase.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.913
FIG4	pikfyve	ENSLBEP00000026979	ENSLBEP00000029703	FIG4 phosphoinositide 5-phosphatase.	Phosphoinositide kinase, FYVE finger containing.	0.998
LOC109984194	ENSLBEP00000023422	ENSLBEP00000006625	ENSLBEP00000023422	Inositol polyphosphate-4-phosphatase type I Ab.	Inositol polyphosphate-4-phosphatase type II B.	0.843
LOC109984194	FIG4	ENSLBEP00000006625	ENSLBEP00000026979	Inositol polyphosphate-4-phosphatase type I Ab.	FIG4 phosphoinositide 5-phosphatase.	0.847
LOC109984194	LOC109995533	ENSLBEP00000006625	ENSLBEP00000026709	Inositol polyphosphate-4-phosphatase type I Ab.	Myotubularin 1.	0.847
LOC109984194	impad1	ENSLBEP00000006625	ENSLBEP00000027010	Inositol polyphosphate-4-phosphatase type I Ab.	Inositol monophosphatase domain containing 1.	0.840
LOC109984194	pik3c3	ENSLBEP00000006625	ENSLBEP00000000163	Inositol polyphosphate-4-phosphatase type I Ab.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.854
LOC109984194	pikfyve	ENSLBEP00000006625	ENSLBEP00000029703	Inositol polyphosphate-4-phosphatase type I Ab.	Phosphoinositide kinase, FYVE finger containing.	0.847
LOC109993643	LOC109995351	ENSLBEP00000015100	ENSLBEP00000010393	SAC1 like phosphatidylinositide phosphatase a.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.870
LOC109993643	LOC109995533	ENSLBEP00000015100	ENSLBEP00000026709	SAC1 like phosphatidylinositide phosphatase a.	Myotubularin 1.	0.849
LOC109993643	cdipt	ENSLBEP00000015100	ENSLBEP00000008125	SAC1 like phosphatidylinositide phosphatase a.	CDP-diacylglycerol--inositol 3-phosphatidyltransferase.	0.870

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

0.000135

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060393

Regulation of pathway-restricted SMAD protein phosphorylation

9 of 62

2.45

8.0

6.33e-18

GO:0010862

Positive regulation of pathway-restricted SMAD protein phosphorylation

8 of 50

2.49

7.33

5.80e-16

GO:0090100

Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

9 of 89

2.29

7.07

8.89e-17

GO:0060395

SMAD protein signal transduction

8 of 62

2.4

6.86

2.28e-15

GO:0030509

BMP signaling pathway

8 of 71

2.34

6.59

4.50e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005125

Cytokine activity

11 of 118

2.26

8.55

6.47e-22

GO:0070700

BMP receptor binding

7 of 13

3.02

8.55

8.19e-17

GO:0008083

Growth factor activity

9 of 141

2.09

6.06

6.14e-16

GO:0039706

Co-receptor binding

2 of 7

2.74

1.49

0.0019

GO:0036122

BMP binding

2 of 11

2.55

1.32

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005615

Extracellular space

11 of 1221

1.24

1.98

2.76e-11

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35923711

(2022) Genome-wide identification, characterization and expression analysis of the BMP family associated with beak-like teeth in Oplegnathus.

6 of 14

2.92

6.59

4.08e-13

PMID:27609345

(2016) The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate.

5 of 60

2.21

3.34

1.53e-07

PMID:26952007

(2016) Goldfish morphology as a model for evolutionary developmental biology.

3 of 6

2.99

2.78

8.60e-06

PMID:33463017

(2020) Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary transition in ray-finned fishes.

3 of 14

2.62

2.36

4.29e-05

PMID:25238963

(2014) Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.

3 of 13

2.65

2.36

4.29e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23582

TGF-beta, propeptide, and BMP binding

11 of 28

2.88

13.57

7.29e-28

CL:23584

TGF-beta, propeptide, and Activin types I and II receptor domain

8 of 22

2.85

9.43

4.60e-19

CL:23586

Activin types I and II receptor domain, and BMP receptor binding

7 of 17

2.9

8.32

1.31e-16

CL:23588

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

4 of 11

2.85

4.13

2.18e-08

CL:23590

Activin types I and II receptor domain, and Cell proliferation involved in kidney development

2 of 6

2.81

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru04350

TGF-beta signaling pathway

11 of 110

2.29

9.16

1.97e-23

tru04060

Cytokine-cytokine receptor interaction

9 of 176

2.0

5.6

1.00e-15

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2129379

Molecules associated with elastic fibres

8 of 44

2.55

7.66

1.88e-16

MAP-1566948

Elastic fibre formation

8 of 57

2.44

7.17

6.30e-16

MAP-1474244

Extracellular matrix organization

8 of 424

1.56

2.72

2.24e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

6 of 1157

1.0

0.65

0.0140

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0339

Growth factor

9 of 95

2.27

7.19

1.93e-17

KW-0964

Secreted

9 of 231

1.88

4.79

2.17e-14

KW-1015

Disulfide bond

10 of 1039

1.27

2.03

9.00e-11

KW-0732

Signal

9 of 2128

0.91

0.96

3.70e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00688

TGF-beta propeptide

9 of 35

2.7

9.63

3.47e-20

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001111

TGF-beta, propeptide

9 of 26

2.83

10.33

4.56e-21

IPR029034

Cystine-knot cytokine

11 of 72

2.47

10.25

9.14e-24

IPR017948

Transforming growth factor beta, conserved site

9 of 32

2.74

9.89

1.51e-20

IPR015615

Transforming growth factor-beta-related

9 of 32

2.74

9.89

1.51e-20

IPR001839

Transforming growth factor-beta, C-terminal

9 of 37

2.67

9.61

2.84e-20

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00204

Transforming growth factor-beta (TGF-beta) family

9 of 47

2.57

9.04

1.25e-19

SM00041

C-terminal cystine knot-like domain (CTCK)

2 of 20

2.29

0.91

0.0214

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