ENSLBEP00000033101 protein (Labrus bergylta)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSLBEP00000033101

Uncharacterized protein. (419 aa)

Predicted Functional Partners:

ak9

0.865

ENSLBEP00000033866

0.699

LOC109985360

0.596

ENSLBEP00000011245

0.566

YTHDC2

0.566

ENSLBEP00000004591

0.541

ENSLBEP00000030295

0.541

sgk3

0.529

LOC109987455

0.523

lamtor2

0.458

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000004591	ENSLBEP00000030295	ENSLBEP00000004591	ENSLBEP00000030295	NDK domain-containing protein.	annotation not available	0.905
ENSLBEP00000004591	ENSLBEP00000033101	ENSLBEP00000004591	ENSLBEP00000033101	NDK domain-containing protein.	Uncharacterized protein.	0.541
ENSLBEP00000004591	LOC109987455	ENSLBEP00000004591	ENSLBEP00000033214	NDK domain-containing protein.	Cytochrome b5 reductase 4.	0.919
ENSLBEP00000004591	ak9	ENSLBEP00000004591	ENSLBEP00000027171	NDK domain-containing protein.	Adenylate kinase 9.	0.942
ENSLBEP00000011245	ENSLBEP00000033101	ENSLBEP00000011245	ENSLBEP00000033101	YTH domain-containing protein.	Uncharacterized protein.	0.566
ENSLBEP00000011245	LOC109985360	ENSLBEP00000011245	ENSLBEP00000003318	YTH domain-containing protein.	BRCA1 associated RING domain 1.	0.677
ENSLBEP00000011245	YTHDC2	ENSLBEP00000011245	ENSLBEP00000037438	YTH domain-containing protein.	YTH domain containing 2.	0.713
ENSLBEP00000030295	ENSLBEP00000004591	ENSLBEP00000030295	ENSLBEP00000004591	annotation not available	NDK domain-containing protein.	0.905
ENSLBEP00000030295	ENSLBEP00000033101	ENSLBEP00000030295	ENSLBEP00000033101	annotation not available	Uncharacterized protein.	0.541
ENSLBEP00000030295	LOC109987455	ENSLBEP00000030295	ENSLBEP00000033214	annotation not available	Cytochrome b5 reductase 4.	0.919
ENSLBEP00000030295	ak9	ENSLBEP00000030295	ENSLBEP00000027171	annotation not available	Adenylate kinase 9.	0.942
ENSLBEP00000033101	ENSLBEP00000004591	ENSLBEP00000033101	ENSLBEP00000004591	Uncharacterized protein.	NDK domain-containing protein.	0.541
ENSLBEP00000033101	ENSLBEP00000011245	ENSLBEP00000033101	ENSLBEP00000011245	Uncharacterized protein.	YTH domain-containing protein.	0.566
ENSLBEP00000033101	ENSLBEP00000030295	ENSLBEP00000033101	ENSLBEP00000030295	Uncharacterized protein.	annotation not available	0.541
ENSLBEP00000033101	ENSLBEP00000033866	ENSLBEP00000033101	ENSLBEP00000033866	Uncharacterized protein.	Uncharacterized protein.	0.699
ENSLBEP00000033101	LOC109985360	ENSLBEP00000033101	ENSLBEP00000003318	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.596
ENSLBEP00000033101	LOC109987455	ENSLBEP00000033101	ENSLBEP00000033214	Uncharacterized protein.	Cytochrome b5 reductase 4.	0.523
ENSLBEP00000033101	YTHDC2	ENSLBEP00000033101	ENSLBEP00000037438	Uncharacterized protein.	YTH domain containing 2.	0.566
ENSLBEP00000033101	ak9	ENSLBEP00000033101	ENSLBEP00000027171	Uncharacterized protein.	Adenylate kinase 9.	0.865
ENSLBEP00000033101	lamtor2	ENSLBEP00000033101	ENSLBEP00000021419	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.458

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.839

expected number of edges:

11

PPI enrichment p-value:

2.44e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046463

Acylglycerol biosynthetic process

6 of 26

2.76

5.88

6.00e-12

GO:0045017

Glycerolipid biosynthetic process

7 of 230

1.88

3.59

1.20e-09

GO:0008610

Lipid biosynthetic process

9 of 619

1.56

2.86

2.37e-10

GO:0006651

Diacylglycerol biosynthetic process

3 of 10

2.87

2.71

1.11e-05

GO:0044255

Cellular lipid metabolic process

10 of 1058

1.37

2.29

2.37e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

8 of 66

2.48

7.21

9.01e-16

GO:0016411

Acylglycerol O-acyltransferase activity

6 of 23

2.81

6.45

5.29e-13

GO:0050252

Retinol O-fatty-acyltransferase activity

2 of 2

3.39

1.88

0.00041

GO:0004168

Dolichol kinase activity

2 of 2

3.39

1.88

0.00041

GO:0004144

Diacylglycerol O-acyltransferase activity

2 of 2

3.39

1.88

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990578

Perinuclear endoplasmic reticulum membrane

2 of 2

3.39

2.07

0.00019

GO:0005789

Endoplasmic reticulum membrane

8 of 1041

1.28

1.65

8.83e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:35114

Acylglycerol biosynthetic process, and Sterol O-acyltransferase, ACAT/DAG/ARE types

5 of 21

2.77

4.72

1.31e-09

CL:34938

Glycerolipid metabolism, and Synthesis of PA

6 of 119

2.1

3.76

6.76e-09

CL:45587

Synthesis of dolichyl-phosphate mannose, and Dolichol kinase activity

2 of 6

2.92

1.41

0.0028

CL:35142

Diacylglycerol acyltransferase, and Sterol O-acyltransferase, ACAT/DAG/ARE types

2 of 5

3.0

1.41

0.0028

CL:35117

Diacylglycerol acyltransferase , and Lipin, middle domain

2 of 5

3.0

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00561

Glycerolipid metabolism

6 of 151

1.99

3.71

2.95e-09

map00564

Glycerophospholipid metabolism

3 of 226

1.52

0.95

0.0091

map00510

N-Glycan biosynthesis

2 of 76

1.81

0.8

0.0288

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75109

Triglyceride biosynthesis

5 of 20

2.79

5.04

3.25e-10

MAP-8979227

Triglyceride metabolism

5 of 38

2.51

4.39

2.94e-09

MAP-9640463

Wax biosynthesis

2 of 5

3.0

1.66

0.0010

MAP-446199

Synthesis of Dolichyl-phosphate

2 of 7

2.85

1.56

0.0015

MAP-1483206

Glycerophospholipid biosynthesis

4 of 209

1.68

1.51

0.00048

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000000

Tissues, cell types and enzyme sources

11 of 16941

0.21

0.2

0.0480

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990578

Perinuclear endoplasmic reticulum membrane

3 of 5

3.17

1.77e-06

GOCC:0042175

Nuclear outer membrane-endoplasmic reticulum membrane network

7 of 388

1.65

2.63

6.25e-08

GOCC:0005783

Endoplasmic reticulum

7 of 698

1.4

1.83

1.77e-06

GOCC:0098827

Endoplasmic reticulum subcompartment

4 of 186

1.73

1.69

0.00019

GOCC:0005789

Endoplasmic reticulum membrane

4 of 366

1.43

1.15

0.0018

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03982

Diacylglycerol acyltransferase

4 of 4

3.39

4.75

2.51e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007130

Diacylglycerol acyltransferase

4 of 4

3.39

4.48

7.73e-09

IPR032974

Polyprenol kinase family

2 of 2

3.39

1.37

0.0034

IPR003386

Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

2 of 2

3.39

1.37

0.0034

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