LOC109995015 protein (Labrus bergylta) - STRING interaction network

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Predicted Interactions

gene neighborhood

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LOC109995015

Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)

Predicted Functional Partners:

ENSLBEP00000028987

0.860

LOC109999093

0.860

ENSLBEP00000036195

0.860

LOC109996670

0.853

f2rl3

0.853

F2RL2

0.853

F2R

0.844

F2R-2

0.844

met

0.804

mst1r

0.804

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000028987	F2R	ENSLBEP00000028987	ENSLBEP00000036209	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	Coagulation factor II thrombin receptor.	0.728
ENSLBEP00000028987	F2R-2	ENSLBEP00000028987	ENSLBEP00000036282	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	Coagulation factor II thrombin receptor.	0.732
ENSLBEP00000028987	LOC109995015	ENSLBEP00000028987	ENSLBEP00000034276	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.860
ENSLBEP00000036195	LOC109995015	ENSLBEP00000036195	ENSLBEP00000034276	Coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.860
F2R	ENSLBEP00000028987	ENSLBEP00000036209	ENSLBEP00000028987	Coagulation factor II thrombin receptor.	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	0.728
F2R	LOC109995015	ENSLBEP00000036209	ENSLBEP00000034276	Coagulation factor II thrombin receptor.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.844
F2R-2	ENSLBEP00000028987	ENSLBEP00000036282	ENSLBEP00000028987	Coagulation factor II thrombin receptor.	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	0.732
F2R-2	LOC109995015	ENSLBEP00000036282	ENSLBEP00000034276	Coagulation factor II thrombin receptor.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.844
F2RL2	LOC109995015	ENSLBEP00000036330	ENSLBEP00000034276	Coagulation factor II thrombin receptor like 2.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.853
LOC109995015	ENSLBEP00000028987	ENSLBEP00000034276	ENSLBEP00000028987	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.	0.860
LOC109995015	ENSLBEP00000036195	ENSLBEP00000034276	ENSLBEP00000036195	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1.	0.860
LOC109995015	F2R	ENSLBEP00000034276	ENSLBEP00000036209	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor.	0.844
LOC109995015	F2R-2	ENSLBEP00000034276	ENSLBEP00000036282	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor.	0.844
LOC109995015	F2RL2	ENSLBEP00000034276	ENSLBEP00000036330	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II thrombin receptor like 2.	0.853
LOC109995015	LOC109996670	ENSLBEP00000034276	ENSLBEP00000028972	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II (thrombin) receptor-like 2.	0.853
LOC109995015	LOC109999093	ENSLBEP00000034276	ENSLBEP00000036185	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2.	0.860
LOC109995015	f2rl3	ENSLBEP00000034276	ENSLBEP00000032115	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.853
LOC109995015	met	ENSLBEP00000034276	ENSLBEP00000003943	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	MET proto-oncogene, receptor tyrosine kinase.	0.804
LOC109995015	mst1r	ENSLBEP00000034276	ENSLBEP00000024621	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Macrophage stimulating 1 receptor b.	0.804
LOC109996670	LOC109995015	ENSLBEP00000028972	ENSLBEP00000034276	Coagulation factor II (thrombin) receptor-like 2.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.853

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009165

Nucleotide biosynthetic process

6 of 182

1.75

2.29

3.91e-06

GO:0009152

Purine ribonucleotide biosynthetic process

5 of 122

1.84

2.21

1.37e-05

GO:0009132

Nucleoside diphosphate metabolic process

4 of 69

1.99

2.17

3.33e-05

GO:0090407

Organophosphate biosynthetic process

7 of 397

1.47

1.89

3.91e-06

GO:0009141

Nucleoside triphosphate metabolic process

4 of 119

1.75

1.72

0.00018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

4 of 29

2.37

2.68

7.11e-06

GO:0019205

Nucleobase-containing compound kinase activity

4 of 40

2.23

2.51

1.17e-05

GO:0004550

Nucleoside diphosphate kinase activity

3 of 15

2.53

2.13

0.00011

GO:0004017

Adenylate kinase activity

2 of 10

2.53

1.02

0.0138

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35194983

(2022) Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation.

7 of 37

2.5

6.06

5.93e-13

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9802

Purine metabolism, and Interconversion of nucleotide di- and triphosphates

8 of 90

2.18

5.5

2.87e-13

CL:9804

Purine metabolism

7 of 76

2.19

5.05

6.68e-12

CL:9865

Mixed, incl. Purine ribonucleoside monophosphate biosynthetic process, and Uridine-diphosphatase activity

4 of 26

2.42

3.14

8.94e-07

CL:9919

Adenylate kinase activity, and dATP metabolic process

3 of 10

2.71

2.58

1.74e-05

CL:9923

Adenylate kinase activity

2 of 5

2.83

1.46

0.0022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

acs00230

Purine metabolism

8 of 117

2.06

5.32

8.91e-14

acs00240

Pyrimidine metabolism

3 of 52

1.99

1.82

0.00022

acs00730

Thiamine metabolism

2 of 13

2.42

1.54

0.0014

acs01100

Metabolic pathways

8 of 1303

1.02

1.1

6.73e-06

acs00983

Drug metabolism - other enzymes

2 of 51

1.82

0.94

0.0143

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

4 of 34

2.3

2.63

7.91e-06

MAP-15869

Metabolism of nucleotides

5 of 122

1.84

2.29

7.91e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 5

3.01

2.37

4.96e-05

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 6

2.93

2.36

4.96e-05

IPR001564

Nucleoside diphosphate kinase

2 of 4

2.93

1.13

0.0092

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 6

2.93

2.75

9.68e-06

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