drc3 protein (Labrus bergylta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

drc3

Dynein regulatory complex subunit 3. (471 aa)

Predicted Functional Partners:

LOC110001607

0.893

LOC109996136

0.810

LOC109979241

0.803

ENSLBEP00000020731

0.803

LOC110001788

0.803

ENSLBEP00000000424

0.785

ENSLBEP00000001556

0.785

LOC109980659

0.785

LOC109975356

0.780

ntng1

0.780

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000424	ENSLBEP00000020731	ENSLBEP00000000424	ENSLBEP00000020731	Uncharacterized protein.	Adenylate kinase 7a.	0.495
ENSLBEP00000000424	LOC109979241	ENSLBEP00000000424	ENSLBEP00000018229	Uncharacterized protein.	Adenylate kinase 7b.	0.495
ENSLBEP00000000424	LOC109996136	ENSLBEP00000000424	ENSLBEP00000010010	Uncharacterized protein.	F-box protein 36b.	0.723
ENSLBEP00000000424	LOC110001607	ENSLBEP00000000424	ENSLBEP00000009926	Uncharacterized protein.	Radial spoke head component 4A.	0.791
ENSLBEP00000000424	LOC110001788	ENSLBEP00000000424	ENSLBEP00000020858	Uncharacterized protein.	Adenylate kinase 7b.	0.495
ENSLBEP00000000424	drc3	ENSLBEP00000000424	ENSLBEP00000035765	Uncharacterized protein.	Dynein regulatory complex subunit 3.	0.785
ENSLBEP00000001556	ENSLBEP00000020731	ENSLBEP00000001556	ENSLBEP00000020731	Uncharacterized protein.	Adenylate kinase 7a.	0.495
ENSLBEP00000001556	LOC109979241	ENSLBEP00000001556	ENSLBEP00000018229	Uncharacterized protein.	Adenylate kinase 7b.	0.495
ENSLBEP00000001556	LOC109996136	ENSLBEP00000001556	ENSLBEP00000010010	Uncharacterized protein.	F-box protein 36b.	0.723
ENSLBEP00000001556	LOC110001607	ENSLBEP00000001556	ENSLBEP00000009926	Uncharacterized protein.	Radial spoke head component 4A.	0.791
ENSLBEP00000001556	LOC110001788	ENSLBEP00000001556	ENSLBEP00000020858	Uncharacterized protein.	Adenylate kinase 7b.	0.495
ENSLBEP00000001556	drc3	ENSLBEP00000001556	ENSLBEP00000035765	Uncharacterized protein.	Dynein regulatory complex subunit 3.	0.785
ENSLBEP00000020731	ENSLBEP00000000424	ENSLBEP00000020731	ENSLBEP00000000424	Adenylate kinase 7a.	Uncharacterized protein.	0.495
ENSLBEP00000020731	ENSLBEP00000001556	ENSLBEP00000020731	ENSLBEP00000001556	Adenylate kinase 7a.	Uncharacterized protein.	0.495
ENSLBEP00000020731	LOC109980659	ENSLBEP00000020731	ENSLBEP00000032597	Adenylate kinase 7a.	Coiled-coil domain containing 114.	0.495
ENSLBEP00000020731	LOC109996136	ENSLBEP00000020731	ENSLBEP00000010010	Adenylate kinase 7a.	F-box protein 36b.	0.723
ENSLBEP00000020731	LOC110001607	ENSLBEP00000020731	ENSLBEP00000009926	Adenylate kinase 7a.	Radial spoke head component 4A.	0.742
ENSLBEP00000020731	drc3	ENSLBEP00000020731	ENSLBEP00000035765	Adenylate kinase 7a.	Dynein regulatory complex subunit 3.	0.803
LOC109975356	drc3	ENSLBEP00000020235	ENSLBEP00000035765	Vav 3 guanine nucleotide exchange factor b.	Dynein regulatory complex subunit 3.	0.780
LOC109975356	ntng1	ENSLBEP00000020235	ENSLBEP00000033193	Vav 3 guanine nucleotide exchange factor b.	Netrin g1a.	0.665

page 1 of 4

Network Stats

number of nodes:

8

number of edges:

18

average node degree:

4.5

avg. local clustering coefficient:

0.624

expected number of edges:

7

PPI enrichment p-value:

0.000379

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003383

Apical constriction

3 of 4

3.15

2.49

3.06e-05

GO:0031032

Actomyosin structure organization

3 of 103

1.74

0.76

0.0328

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20317

Cadherin conserved site, and Plakophilin/Delta catenin

5 of 70

2.13

2.91

1.06e-06

CL:9807

Atrophin-like, and c4 zinc finger in nuclear hormone receptors

3 of 6

2.98

2.87

5.76e-06

CL:20400

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 10

2.75

2.66

1.25e-05

CL:6889

Mixed, incl. FERM domain-containing protein 6-like, and WWC, C2 domain

3 of 12

2.67

2.56

1.82e-05

CL:20403

Limb expression 1, and Retina layer formation

2 of 5

2.88

1.61

0.0012

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

4 of 78

1.99

2.33

1.41e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8943724

Regulation of PTEN gene transcription

3 of 68

1.92

1.03

0.0102

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098592

Cytoplasmic side of apical plasma membrane

3 of 5

3.05

2.77

9.20e-06

GOCC:0035003

Subapical complex

2 of 5

2.88

1.51

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03154

Atrophin-1 family

3 of 3

3.28

2.94

4.75e-06

PF14954

Limb expression 1

2 of 2

3.28

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047145

FERM domain-containing protein 6-like

3 of 3

3.28

2.67

1.53e-05

IPR002951

Atrophin-like

3 of 3

3.28

2.67

1.53e-05

IPR029270

Limb expression 1

2 of 2

3.28

1.49

0.0021

IPR018980

FERM, C-terminal PH-like domain

3 of 35

2.21

1.43

0.0020

IPR018979

FERM, N-terminal

3 of 34

2.22

1.43

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01196

FERM C-terminal PH-like domain

3 of 35

2.21

1.66

0.00070

SM00295

Band 4.1 homologues

3 of 64

1.95

1.37

0.0020

SM01189

The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex PUBMED:10226007. The domain is usually found to the N terminus of a myb-like DNA binding domain SANT ...

2 of 11

2.54

1.26

0.0050

SM00717

SANT SWI3, ADA2, N-CoR and TFIIIB DNA-binding domains

2 of 44

1.93

0.69

0.0498

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