kyat3 protein (Labrus bergylta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

kyat3

Kynurenine aminotransferase 3. (450 aa)

Predicted Functional Partners:

aadat

0.916

got2

0.912

cth

0.908

kmo

0.906

LOC109994457

0.898

afmid

0.894

LOC109999371

0.886

LOC110005061

0.886

eprs1

0.884

ppcs

0.883

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC109994457	aadat	ENSLBEP00000031336	ENSLBEP00000037584	Malate synthase-like.	Aminoadipate aminotransferase.	0.589
LOC109994457	afmid	ENSLBEP00000031336	ENSLBEP00000031707	Malate synthase-like.	Arylformamidase.	0.888
LOC109994457	got2	ENSLBEP00000031336	ENSLBEP00000031692	Malate synthase-like.	Aspartate aminotransferase.	0.575
LOC109994457	kmo	ENSLBEP00000031336	ENSLBEP00000034240	Malate synthase-like.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.480
LOC109994457	kyat3	ENSLBEP00000031336	ENSLBEP00000036878	Malate synthase-like.	Kynurenine aminotransferase 3.	0.898
LOC109999371	aadat	ENSLBEP00000014244	ENSLBEP00000037584	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminoadipate aminotransferase.	0.905
LOC109999371	afmid	ENSLBEP00000014244	ENSLBEP00000031707	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Arylformamidase.	0.924
LOC109999371	kmo	ENSLBEP00000014244	ENSLBEP00000034240	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.986
LOC109999371	kyat3	ENSLBEP00000014244	ENSLBEP00000036878	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine aminotransferase 3.	0.886
LOC110005061	aadat	ENSLBEP00000018054	ENSLBEP00000037584	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminoadipate aminotransferase.	0.905
LOC110005061	afmid	ENSLBEP00000018054	ENSLBEP00000031707	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Arylformamidase.	0.924
LOC110005061	kmo	ENSLBEP00000018054	ENSLBEP00000034240	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.988
LOC110005061	kyat3	ENSLBEP00000018054	ENSLBEP00000036878	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine aminotransferase 3.	0.886
aadat	LOC109994457	ENSLBEP00000037584	ENSLBEP00000031336	Aminoadipate aminotransferase.	Malate synthase-like.	0.589
aadat	LOC109999371	ENSLBEP00000037584	ENSLBEP00000014244	Aminoadipate aminotransferase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.905
aadat	LOC110005061	ENSLBEP00000037584	ENSLBEP00000018054	Aminoadipate aminotransferase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.905
aadat	afmid	ENSLBEP00000037584	ENSLBEP00000031707	Aminoadipate aminotransferase.	Arylformamidase.	0.901
aadat	cth	ENSLBEP00000037584	ENSLBEP00000031951	Aminoadipate aminotransferase.	Cystathionase (cystathionine gamma-lyase), like.	0.451
aadat	got2	ENSLBEP00000037584	ENSLBEP00000031692	Aminoadipate aminotransferase.	Aspartate aminotransferase.	0.945
aadat	kmo	ENSLBEP00000037584	ENSLBEP00000034240	Aminoadipate aminotransferase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.933

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.823

expected number of edges:

13

PPI enrichment p-value:

0.0551

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

5 of 66

2.17

3.32

1.41e-07

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

8 of 278

1.75

3.27

1.18e-09

GO:0030970

Retrograde protein transport, ER to cytosol

3 of 12

2.69

2.54

2.04e-05

GO:0035967

Cellular response to topologically incorrect protein

4 of 89

1.94

2.09

4.33e-05

GO:0071712

ER-associated misfolded protein catabolic process

2 of 8

2.69

1.4

0.0028

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043130

Ubiquitin binding

4 of 80

1.99

1.85

0.00019

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

5 of 6

3.21

6.08

7.11e-12

GO:0140534

Endoplasmic reticulum protein-containing complex

6 of 94

2.09

3.91

2.53e-09

GO:0005789

Endoplasmic reticulum membrane

6 of 849

1.14

1.01

0.00065

GO:0098796

Membrane protein complex

6 of 1140

1.01

0.83

0.0015

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8599

Mixed, incl. Domain present in ubiquitin-regulatory proteins, and Josephin domain DUBs

6 of 20

2.77

6.29

9.29e-13

CL:8556

Mixed, incl. ERAD pathway, and Preribosome binding

7 of 42

2.51

6.19

3.23e-13

CL:8601

Domain present in ubiquitin-regulatory proteins, and Cell division protein 48 (CDC48) N-terminal domain

4 of 12

2.81

3.91

5.34e-08

CL:8615

UAS, and Cell division protein 48 (CDC48) N-terminal domain

3 of 5

3.07

2.98

3.77e-06

CL:8069

VCP-NPL4-UFD1 AAA ATPase complex, and Microtubule severing

3 of 5

3.07

2.98

3.77e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru04141

Protein processing in endoplasmic reticulum

6 of 165

1.85

3.18

1.77e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9755511

KEAP1-NFE2L2 pathway

5 of 106

1.96

2.6

2.56e-06

MAP-110320

Translesion Synthesis by POLH

3 of 29

2.3

1.88

0.00027

MAP-9711123

Cellular response to chemical stress

5 of 217

1.65

1.85

4.18e-05

MAP-8951664

Neddylation

5 of 362

1.43

1.39

0.00027

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

3 of 75

1.89

1.31

0.0025

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034098

VCP-NPL4-UFD1 AAA ATPase complex

4 of 6

3.11

4.33

1.20e-08

GOCC:0036501

UFD1-NPL4 complex

2 of 2

3.29

1.81

0.00054

GOCC:0005789

Endoplasmic reticulum membrane

5 of 307

1.5

1.49

0.00021

GOCC:0005783

Endoplasmic reticulum

5 of 581

1.22

1.0

0.0018

GOCC:0098796

Membrane protein complex

5 of 930

1.02

0.66

0.0126

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14555

UBA-like domain

3 of 15

2.59

2.01

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006577

UAS

2 of 3

3.11

1.02

0.0146

IPR001012

UBX domain

2 of 10

2.59

0.73

0.0481

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00594

UAS

3 of 4

3.16

3.07

2.74e-06

SM00166

Domain present in ubiquitin-regulatory proteins

3 of 9

2.81

2.76

8.61e-06

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