ENSLBEP00000037225 protein (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSLBEP00000037225

annotation not available (211 aa)

Predicted Functional Partners:

LOC109991812

0.825

bax

0.825

cast

0.795

capns1

0.783

ENSLBEP00000022374

0.658

LOC109998905

0.658

LOC109998896

0.658

lrguk

0.611

pef1

0.573

LOC109992369

0.573

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000022374	ENSLBEP00000037225	ENSLBEP00000022374	ENSLBEP00000037225	Uncharacterized protein.	annotation not available	0.658
ENSLBEP00000022374	LOC109991812	ENSLBEP00000022374	ENSLBEP00000009839	Uncharacterized protein.	Uncharacterized protein.	0.836
ENSLBEP00000022374	bax	ENSLBEP00000022374	ENSLBEP00000030990	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.964
ENSLBEP00000037225	ENSLBEP00000022374	ENSLBEP00000037225	ENSLBEP00000022374	annotation not available	Uncharacterized protein.	0.658
ENSLBEP00000037225	LOC109991812	ENSLBEP00000037225	ENSLBEP00000009839	annotation not available	Uncharacterized protein.	0.825
ENSLBEP00000037225	LOC109992369	ENSLBEP00000037225	ENSLBEP00000011871	annotation not available	Grancalcin.	0.573
ENSLBEP00000037225	LOC109998896	ENSLBEP00000037225	ENSLBEP00000028690	annotation not available	Zgc:153993.	0.658
ENSLBEP00000037225	LOC109998905	ENSLBEP00000037225	ENSLBEP00000028657	annotation not available	Uncharacterized protein.	0.658
ENSLBEP00000037225	bax	ENSLBEP00000037225	ENSLBEP00000030990	annotation not available	BCL2 associated X, apoptosis regulator a.	0.825
ENSLBEP00000037225	capns1	ENSLBEP00000037225	ENSLBEP00000038283	annotation not available	Calpain, small subunit 1 b.	0.783
ENSLBEP00000037225	cast	ENSLBEP00000037225	ENSLBEP00000036216	annotation not available	Uncharacterized protein.	0.795
ENSLBEP00000037225	lrguk	ENSLBEP00000037225	ENSLBEP00000023155	annotation not available	Leucine-rich repeats and guanylate kinase domain containing.	0.611
ENSLBEP00000037225	pef1	ENSLBEP00000037225	ENSLBEP00000003476	annotation not available	Penta-EF-hand domain containing 1.	0.573
LOC109991812	ENSLBEP00000022374	ENSLBEP00000009839	ENSLBEP00000022374	Uncharacterized protein.	Uncharacterized protein.	0.836
LOC109991812	ENSLBEP00000037225	ENSLBEP00000009839	ENSLBEP00000037225	Uncharacterized protein.	annotation not available	0.825
LOC109991812	LOC109998896	ENSLBEP00000009839	ENSLBEP00000028690	Uncharacterized protein.	Zgc:153993.	0.843
LOC109991812	LOC109998905	ENSLBEP00000009839	ENSLBEP00000028657	Uncharacterized protein.	Uncharacterized protein.	0.840
LOC109992369	ENSLBEP00000037225	ENSLBEP00000011871	ENSLBEP00000037225	Grancalcin.	annotation not available	0.573
LOC109992369	cast	ENSLBEP00000011871	ENSLBEP00000036216	Grancalcin.	Uncharacterized protein.	0.892
LOC109998896	ENSLBEP00000037225	ENSLBEP00000028690	ENSLBEP00000037225	Zgc:153993.	annotation not available	0.658

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

4

PPI enrichment p-value:

0.136

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043484

Regulation of RNA splicing

6 of 152

1.85

2.6

1.17e-06

GO:0000398

mRNA splicing, via spliceosome

6 of 285

1.58

1.84

2.31e-05

GO:0050684

Regulation of mRNA processing

4 of 136

1.72

1.41

0.0010

GO:0048024

Regulation of mRNA splicing, via spliceosome

3 of 105

1.71

0.81

0.0252

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016604

Nuclear body

6 of 757

1.15

0.93

0.0020

GO:0016607

Nuclear speck

4 of 398

1.26

0.81

0.0109

GO:0005654

Nucleoplasm

9 of 3218

0.7

0.54

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14339

Mixed, incl. SRSF7, RNA recognition motif, and Primary miRNA processing

6 of 13

2.92

6.49

6.46e-13

CL:14341

Mixed, incl. DNA topoisomerase binding, and SRSF7, RNA recognition motif

4 of 6

3.08

4.61

3.57e-09

CL:15958

Mixed, incl. THRAP3/BCLAF1 family, and Arginine/Serine-Rich protein 1

3 of 8

2.83

2.84

5.99e-06

CL:14353

Mixed, incl. SRSF7, RNA recognition motif, and Primary miRNA processing

2 of 6

2.78

1.5

0.0019

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

5 of 337

1.43

1.41

0.00022

map05168

Herpes simplex virus 1 infection

4 of 507

1.15

0.67

0.0221

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

5 of 380

1.37

1.1

0.0020

MAP-72172

mRNA Splicing

5 of 393

1.36

1.09

0.0020

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 519

1.24

0.95

0.0030

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 89

1.91

1.74

0.00027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

5 of 377

1.38

1.3

0.00038

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

5 of 278

1.51

1.2

0.0018

IPR035979

RNA-binding domain superfamily

5 of 305

1.47

1.17

0.0018

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

5 of 320

1.45

1.16

0.0018

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

5 of 271

1.52

0.00018

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