node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SYN_00471 | kdsB | SYN_00471 | SYN_02057 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.906 |
SYN_00471 | lpxA | SYN_00471 | SYN_01567 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.871 |
SYN_00471 | lpxB | SYN_00471 | SYN_01565 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.878 |
SYN_00471 | lpxC | SYN_00471 | SYN_00756 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.873 |
SYN_00471 | lpxD | SYN_00471 | SYN_01568 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-[3-hydroxymyristoyl] glucosamine; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.880 |
SYN_00471 | lpxK | SYN_00471 | SYN_01563 | Arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.902 |
SYN_00921 | SYN_01695 | SYN_00921 | SYN_01695 | Outer membrane protein. | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | 0.617 |
SYN_00921 | kdsB | SYN_00921 | SYN_02057 | Outer membrane protein. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.404 |
SYN_00921 | lpxA | SYN_00921 | SYN_01567 | Outer membrane protein. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.848 |
SYN_00921 | lpxB | SYN_00921 | SYN_01565 | Outer membrane protein. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.647 |
SYN_00921 | lpxC | SYN_00921 | SYN_00756 | Outer membrane protein. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.575 |
SYN_00921 | lpxD | SYN_00921 | SYN_01568 | Outer membrane protein. | UDP-3-O-[3-hydroxymyristoyl] glucosamine; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.926 |
SYN_00921 | lpxK | SYN_00921 | SYN_01563 | Outer membrane protein. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.626 |
SYN_01695 | SYN_00921 | SYN_01695 | SYN_00921 | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | Outer membrane protein. | 0.617 |
SYN_01695 | lpxA | SYN_01695 | SYN_01567 | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.962 |
SYN_01695 | lpxB | SYN_01695 | SYN_01565 | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.544 |
SYN_01695 | lpxC | SYN_01695 | SYN_00756 | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.430 |
SYN_01695 | lpxD | SYN_01695 | SYN_01568 | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase. | UDP-3-O-[3-hydroxymyristoyl] glucosamine; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.857 |
SYN_02437 | lpxA | SYN_02437 | SYN_01567 | UDP-N-acetylglucosamine pyrophosphorylase. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.846 |
SYN_02437 | murA | SYN_02437 | SYN_01793 | UDP-N-acetylglucosamine pyrophosphorylase. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.944 |