node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLUMA_CG001781 | CLUMA_CG008012 | A0A1J1HJA6 | A0A1J1I2T1 | CLUMA_CG001781, isoform A. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.797 |
CLUMA_CG001781 | CLUMA_CG012137 | A0A1J1HJA6 | A0A1J1IGY6 | CLUMA_CG001781, isoform A. | CLUMA_CG012137, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.731 |
CLUMA_CG001781 | CLUMA_CG012816 | A0A1J1HJA6 | A0A1J1IM03 | CLUMA_CG001781, isoform A. | CLUMA_CG012816, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.731 |
CLUMA_CG001781 | CLUMA_CG014275 | A0A1J1HJA6 | A0A1J1ILJ6 | CLUMA_CG001781, isoform A. | CLUMA_CG014275, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.731 |
CLUMA_CG001781 | CLUMA_CG016369 | A0A1J1HJA6 | A0A1J1IUC9 | CLUMA_CG001781, isoform A. | CLUMA_CG016369, isoform A. | 0.718 |
CLUMA_CG001781 | CLUMA_CG017162 | A0A1J1HJA6 | A0A1J1IZP3 | CLUMA_CG001781, isoform A. | CLUMA_CG017162, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.963 |
CLUMA_CG001781 | CLUMA_CG017779 | A0A1J1HJA6 | A0A1J1IX38 | CLUMA_CG001781, isoform A. | CLUMA_CG017779, isoform A. | 0.731 |
CLUMA_CG001781 | CLUMA_CG020592 | A0A1J1HJA6 | A0A1J1J5E1 | CLUMA_CG001781, isoform A. | CLUMA_CG020592, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.731 |
CLUMA_CG008012 | CLUMA_CG001781 | A0A1J1I2T1 | A0A1J1HJA6 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG001781, isoform A. | 0.797 |
CLUMA_CG008012 | CLUMA_CG008076 | A0A1J1I2T1 | A0A1J1I2P3 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Small ubiquitin-related modifier. | 0.805 |
CLUMA_CG008012 | CLUMA_CG012137 | A0A1J1I2T1 | A0A1J1IGY6 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG012137, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.608 |
CLUMA_CG008012 | CLUMA_CG012816 | A0A1J1I2T1 | A0A1J1IM03 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG012816, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.608 |
CLUMA_CG008012 | CLUMA_CG014275 | A0A1J1I2T1 | A0A1J1ILJ6 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG014275, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.608 |
CLUMA_CG008012 | CLUMA_CG016369 | A0A1J1I2T1 | A0A1J1IUC9 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG016369, isoform A. | 0.624 |
CLUMA_CG008012 | CLUMA_CG017162 | A0A1J1I2T1 | A0A1J1IZP3 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG017162, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.892 |
CLUMA_CG008012 | CLUMA_CG017173 | A0A1J1I2T1 | A0A1J1IWX9 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Small ubiquitin-related modifier. | 0.805 |
CLUMA_CG008012 | CLUMA_CG017779 | A0A1J1I2T1 | A0A1J1IX38 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG017779, isoform A. | 0.608 |
CLUMA_CG008012 | CLUMA_CG020592 | A0A1J1I2T1 | A0A1J1J5E1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | CLUMA_CG020592, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.610 |
CLUMA_CG008076 | CLUMA_CG008012 | A0A1J1I2P3 | A0A1J1I2T1 | Small ubiquitin-related modifier. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.805 |
CLUMA_CG008076 | CLUMA_CG012137 | A0A1J1I2P3 | A0A1J1IGY6 | Small ubiquitin-related modifier. | CLUMA_CG012137, isoform A; Belongs to the ubiquitin-conjugating enzyme family. | 0.791 |