STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BVC80_4733g1AP180 N-terminal homology (ANTH) domain. (451 aa)    
Predicted Functional Partners:
BVC80_1711g18
AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.
   
 0.692
BVC80_9077g60
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
    
 0.625
BVC80_9093g80
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
    
 0.625
BVC80_9085g47
EPS15 homology (EH).
    
 0.607
BVC80_703g5
EPS15 homology (EH).
    
 0.607
BVC80_1653g59
Clathrin adaptor; Belongs to the adaptor complexes medium subunit family.
    
 0.595
BVC80_479g21
Rhodanese-like domain.
    
 0.595
BVC80_1431g41
AP-1 complex subunit gamma.
   
 0.560
BVC80_261g23
AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family.
   
 0.560
BVC80_1719g94
Ubiquitin domain.
    
  0.557
Your Current Organism:
Macleaya cordata
NCBI taxonomy Id: 56857
Other names: M. cordata, Macleaya cordata (Willd.) R.Br.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.