STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PV07_00465NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. (538 aa)    
Predicted Functional Partners:
PV07_11441
E2_bind domain-containing protein.
   
 0.999
PV07_07745
NEDD8-conjugating enzyme UBC12; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.983
PV07_01839
Uncharacterized protein.
  
 0.890
PV07_07281
Autophagy-related protein 3.
    
 0.884
PV07_03204
Ubiquitin-like domain-containing protein.
   
 0.884
PV07_09193
HECT domain-containing protein.
    
 0.862
PV07_02102
Autophagy-related protein.
   
 0.842
PV07_11560
Zn(2)-C6 fungal-type domain-containing protein.
   
 0.830
URM1
Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...]
    
 0.816
PV07_10408
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.813
Your Current Organism:
Cladophialophora immunda
NCBI taxonomy Id: 569365
Other names: C. immunda, CBS 834.96, Cladophialophora sp. CBS 834.96, Cladophialophora sp. HB-2008
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.