APD08509.1 protein (Thermus brockianus) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

APD08509.1

Putative acyl-CoA dehydrogenase. (368 aa)

Predicted Functional Partners:

APD08508.1

0.986

APD08253.1

0.963

APD09554.1

0.947

APD08269.1

0.941

APD08697.1

0.941

APD10289.1

0.941

APD08265.1

0.925

APD08854.1

0.925

APD10024.1

0.924

APD08255.1

0.910

Your Current Organism:

Thermus brockianus

NCBI taxonomy Id: 56956
Other names: JCM 11602, NCIB 12676, NCIB:12676, NCIMB 12676, T. brockianus, strain YS38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APD08253.1	APD08255.1	A0O31_00017	A0O31_00019	Electron transfer flavoprotein subunit alpha.	Acetyl-coenzyme A dehydrogenase medium subunit.	0.996
APD08253.1	APD08265.1	A0O31_00017	A0O31_00031	Electron transfer flavoprotein subunit alpha.	acyl-CoA dehydrogenase, short-chain specific (AidB protein).	0.862
APD08253.1	APD08269.1	A0O31_00017	A0O31_00035	Electron transfer flavoprotein subunit alpha.	Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.413
APD08253.1	APD08508.1	A0O31_00017	A0O31_00290	Electron transfer flavoprotein subunit alpha.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.401
APD08253.1	APD08509.1	A0O31_00017	A0O31_00291	Electron transfer flavoprotein subunit alpha.	Putative acyl-CoA dehydrogenase.	0.963
APD08253.1	APD08697.1	A0O31_00017	A0O31_00489	Electron transfer flavoprotein subunit alpha.	Acetyl coenzyme A acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.420
APD08253.1	APD10024.1	A0O31_00017	A0O31_01949	Electron transfer flavoprotein subunit alpha.	glutaryl-CoA dehydrogenase.	0.929
APD08253.1	APD10289.1	A0O31_00017	A0O31_02255	Electron transfer flavoprotein subunit alpha.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.414
APD08255.1	APD08253.1	A0O31_00019	A0O31_00017	Acetyl-coenzyme A dehydrogenase medium subunit.	Electron transfer flavoprotein subunit alpha.	0.996
APD08255.1	APD08265.1	A0O31_00019	A0O31_00031	Acetyl-coenzyme A dehydrogenase medium subunit.	acyl-CoA dehydrogenase, short-chain specific (AidB protein).	0.925
APD08255.1	APD08269.1	A0O31_00019	A0O31_00035	Acetyl-coenzyme A dehydrogenase medium subunit.	Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.944
APD08255.1	APD08508.1	A0O31_00019	A0O31_00290	Acetyl-coenzyme A dehydrogenase medium subunit.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.945
APD08255.1	APD08509.1	A0O31_00019	A0O31_00291	Acetyl-coenzyme A dehydrogenase medium subunit.	Putative acyl-CoA dehydrogenase.	0.910
APD08255.1	APD08697.1	A0O31_00019	A0O31_00489	Acetyl-coenzyme A dehydrogenase medium subunit.	Acetyl coenzyme A acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.944
APD08255.1	APD08854.1	A0O31_00019	A0O31_00664	Acetyl-coenzyme A dehydrogenase medium subunit.	propionyl-CoA carboxylase subunit beta.	0.934
APD08255.1	APD09554.1	A0O31_00019	A0O31_01441	Acetyl-coenzyme A dehydrogenase medium subunit.	enoyl-CoA hydratase.	0.947
APD08255.1	APD10024.1	A0O31_00019	A0O31_01949	Acetyl-coenzyme A dehydrogenase medium subunit.	glutaryl-CoA dehydrogenase.	0.918
APD08255.1	APD10289.1	A0O31_00019	A0O31_02255	Acetyl-coenzyme A dehydrogenase medium subunit.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.945
APD08265.1	APD08253.1	A0O31_00031	A0O31_00017	acyl-CoA dehydrogenase, short-chain specific (AidB protein).	Electron transfer flavoprotein subunit alpha.	0.862
APD08265.1	APD08255.1	A0O31_00031	A0O31_00019	acyl-CoA dehydrogenase, short-chain specific (AidB protein).	Acetyl-coenzyme A dehydrogenase medium subunit.	0.925

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016570

Histone modification

6 of 89

1.91

3.1

6.62e-08

GO:0016573

Histone acetylation

4 of 33

2.16

2.75

2.85e-06

GO:0045893

Positive regulation of transcription, DNA-templated

7 of 165

1.71

2.74

6.62e-08

GO:0051123

RNA polymerase II preinitiation complex assembly

3 of 24

2.17

2.03

0.00011

GO:0016578

Histone deubiquitination

2 of 2

3.08

1.94

0.00031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003713

Transcription coactivator activity

4 of 20

2.38

2.78

4.57e-06

GO:0003712

Transcription coregulator activity

5 of 81

1.87

2.41

4.57e-06

GO:0046982

Protein heterodimerization activity

3 of 34

2.02

1.41

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000124

SAGA complex

10 of 19

2.8

11.63

4.29e-24

GO:0046695

SLIK (SAGA-like) complex

3 of 5

2.86

3.2

1.28e-06

GO:0005669

Transcription factor TFIID complex

3 of 17

2.32

2.41

2.30e-05

GO:0043231

Intracellular membrane-bounded organelle

11 of 4898

0.43

0.36

0.00073

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3955

SAGA complex

8 of 17

2.75

8.53

1.66e-17

CL:3960

SAGA complex

6 of 11

2.81

6.68

1.83e-13

CL:3963

SAGA complex

4 of 6

2.9

4.29

1.15e-08

CL:4304

Transcription factor TFIID complex

3 of 10

2.56

2.48

2.35e-05

CL:4305

Transcription factor TFIID complex

2 of 5

2.68

1.49

0.0019

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03022

Basal transcription factors

3 of 72

1.7

1.14

0.0043

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689880

Ub-specific processing proteases

4 of 77

1.79

1.61

0.00040

MAP-5688426

Deubiquitination

4 of 114

1.62

1.37

0.00091

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

3 of 51

1.85

1.24

0.0033

MAP-75953

RNA Polymerase II Transcription Initiation

3 of 51

1.85

1.24

0.0033

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

3 of 51

1.85

1.24

0.0033

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070461

SAGA-type complex

6 of 15

2.68

6.08

1.73e-12

GOCC:0000124

SAGA complex

5 of 13

2.66

5.04

2.28e-10

GOCC:0005654

Nucleoplasm

10 of 287

1.62

3.52

3.17e-13

GOCC:1990234

Transferase complex

8 of 397

1.38

2.14

1.04e-08

GOCC:0071819

DUBm complex

2 of 3

2.9

1.9

0.00035

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

3 of 41

1.94

1.44

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009072

Histone-fold

3 of 29

2.09

1.16

0.0064

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