| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIX91349.1 | glyA | TP70_02740 | TP70_02745 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.840 |
| KIX91349.1 | lacA | TP70_02740 | TP70_04820 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.673 |
| KIX91349.1 | lacB | TP70_02740 | TP70_04815 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.892 |
| glyA | KIX91349.1 | TP70_02745 | TP70_02740 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.840 |
| glyA | lacB | TP70_02745 | TP70_04815 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.925 |
| lacA | KIX91349.1 | TP70_04820 | TP70_02740 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.673 |
| lacA | lacB | TP70_04820 | TP70_04815 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |
| lacA | lacC | TP70_04820 | TP70_04810 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-6-phosphate kinase; Catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.993 |
| lacA | lacD1 | TP70_04820 | TP70_04805 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.933 |
| lacA | lacE | TP70_04820 | TP70_07140 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.832 |
| lacA | lacG | TP70_04820 | TP70_07135 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 6-phospho-beta-galactosidase; Catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 1 family. | 0.900 |
| lacA | prs | TP70_04820 | TP70_10750 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.713 |
| lacA | rpe | TP70_04820 | TP70_07870 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. | 0.759 |
| lacA | rpiA | TP70_04820 | TP70_04275 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. | 0.759 |
| lacB | KIX91349.1 | TP70_04815 | TP70_02740 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.892 |
| lacB | glyA | TP70_04815 | TP70_02745 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
| lacB | lacA | TP70_04815 | TP70_04820 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |
| lacB | lacC | TP70_04815 | TP70_04810 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-6-phosphate kinase; Catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.994 |
| lacB | lacD1 | TP70_04815 | TP70_04805 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.958 |
| lacB | lacE | TP70_04815 | TP70_07140 | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.871 |