| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KIX91049.1 | lacR | TP70_04845 | TP70_04840 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.473 |
| ccpA_2 | fruA | TP70_09435 | TP70_01150 | Catabolite control protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.557 |
| ccpA_2 | lacR | TP70_09435 | TP70_04840 | Catabolite control protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.481 |
| fruA | ccpA_2 | TP70_01150 | TP70_09435 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catabolite control protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.557 |
| fruA | fruK | TP70_01150 | TP70_01155 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.999 |
| fruA | lacA | TP70_01150 | TP70_04820 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.519 |
| fruA | lacB | TP70_01150 | TP70_04815 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.519 |
| fruA | lacC | TP70_01150 | TP70_04810 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-6-phosphate kinase; Catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.999 |
| fruA | lacD1 | TP70_01150 | TP70_04805 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.481 |
| fruA | lacE | TP70_01150 | TP70_07140 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.739 |
| fruA | lacR | TP70_01150 | TP70_04840 | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.861 |
| fruK | fruA | TP70_01155 | TP70_01150 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| fruK | lacA | TP70_01155 | TP70_04820 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.908 |
| fruK | lacB | TP70_01155 | TP70_04815 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.995 |
| fruK | lacD1 | TP70_01155 | TP70_04805 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.966 |
| fruK | lacE | TP70_01155 | TP70_07140 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.983 |
| fruK | lacR | TP70_01155 | TP70_04840 | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.817 |
| gntR | lacR | TP70_07315 | TP70_04840 | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.505 |
| lacA | fruA | TP70_04820 | TP70_01150 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.519 |
| lacA | fruK | TP70_04820 | TP70_01155 | Galactose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.908 |