Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lipLLipoate--protein ligase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (279 aa)    
Predicted Functional Partners:
lplJ
Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.942
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
 
 0.922
eutD
Phosphotransacetylase; In Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.904
lipM
Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.
    
 0.896
gcvH
Glycine cleavage system protein H; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family.
 
 
 0.896
KIX90733.1
Heme peroxidase; May function as heme-dependent peroxidase.
 
     0.766
est
Carboxylesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.751
mecA
Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
  
     0.638
KIX90104.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.603
pdhC_1
Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.588
Your Current Organism:
Staphylococcus microti
NCBI taxonomy Id: 569857
Other names: CCM 4903, CCUG 55861, DSM 22147, NCTC 13832, S. microti, Staphylococcus microti Novakova et al. 2010, Staphylococcus sp. CCM 4903, Staphylococcus sp. CCM 4904, strain 4005-LJ(m)
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