SEO10994.1 protein (Salinihabitans flavidus)

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

SEO10994.1

Adenosylhomocysteinase. (145 aa)

Predicted Functional Partners:

SEP24973.1

0.832

SEO79114.1

0.689

SEO29103.1

0.687

SEO81188.1

0.685

SEP24961.1

0.682

SEO45811.1

0.677

SEO66951.1

0.601

SEO88912.1

0.601

metZ

0.567

SEO70971.1

0.567

Your Current Organism:

Salinihabitans flavidus

NCBI taxonomy Id: 569882
Other names: CCUG 56758, DSM 27842, KCTC 22485, Rhodobacteraceae bacterium ISL-46, S. flavidus, Salinihabitans flavidus Yoon et al. 2009, strain ISL-46

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEO10994.1	SEO29103.1	SAMN04490248_101383	SAMN04490248_103185	Adenosylhomocysteinase.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.687
SEO10994.1	SEO45811.1	SAMN04490248_101383	SAMN04490248_105155	Adenosylhomocysteinase.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.677
SEO10994.1	SEO66951.1	SAMN04490248_101383	SAMN04490248_10918	Adenosylhomocysteinase.	Cysteine synthase A.	0.601
SEO10994.1	SEO70971.1	SAMN04490248_101383	SAMN04490248_11023	Adenosylhomocysteinase.	Cystathionine gamma-synthase.	0.567
SEO10994.1	SEO79114.1	SAMN04490248_101383	SAMN04490248_11282	Adenosylhomocysteinase.	O-acetylhomoserine sulfhydrylase.	0.689
SEO10994.1	SEO81188.1	SAMN04490248_101383	SAMN04490248_1138	Adenosylhomocysteinase.	Homoserine dehydrogenase.	0.685
SEO10994.1	SEO88912.1	SAMN04490248_101383	SAMN04490248_11527	Adenosylhomocysteinase.	Cysteine synthase A.	0.601
SEO10994.1	SEP24961.1	SAMN04490248_101383	SAMN04490248_1533	Adenosylhomocysteinase.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.682
SEO10994.1	SEP24973.1	SAMN04490248_101383	SAMN04490248_1534	Adenosylhomocysteinase.	Methionine synthase I (cobalamin-dependent), methyltransferase domain.	0.832
SEO10994.1	metZ	SAMN04490248_101383	SAMN04490248_10169	Adenosylhomocysteinase.	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.	0.567
SEO29103.1	SEO10994.1	SAMN04490248_103185	SAMN04490248_101383	5-methyltetrahydrofolate--homocysteine methyltransferase.	Adenosylhomocysteinase.	0.687
SEO29103.1	SEO45811.1	SAMN04490248_103185	SAMN04490248_105155	5-methyltetrahydrofolate--homocysteine methyltransferase.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.998
SEO29103.1	SEO66951.1	SAMN04490248_103185	SAMN04490248_10918	5-methyltetrahydrofolate--homocysteine methyltransferase.	Cysteine synthase A.	0.752
SEO29103.1	SEO70971.1	SAMN04490248_103185	SAMN04490248_11023	5-methyltetrahydrofolate--homocysteine methyltransferase.	Cystathionine gamma-synthase.	0.836
SEO29103.1	SEO79114.1	SAMN04490248_103185	SAMN04490248_11282	5-methyltetrahydrofolate--homocysteine methyltransferase.	O-acetylhomoserine sulfhydrylase.	0.931
SEO29103.1	SEO81188.1	SAMN04490248_103185	SAMN04490248_1138	5-methyltetrahydrofolate--homocysteine methyltransferase.	Homoserine dehydrogenase.	0.879
SEO29103.1	SEO88912.1	SAMN04490248_103185	SAMN04490248_11527	5-methyltetrahydrofolate--homocysteine methyltransferase.	Cysteine synthase A.	0.752
SEO29103.1	SEP24961.1	SAMN04490248_103185	SAMN04490248_1533	5-methyltetrahydrofolate--homocysteine methyltransferase.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.995
SEO29103.1	SEP24973.1	SAMN04490248_103185	SAMN04490248_1534	5-methyltetrahydrofolate--homocysteine methyltransferase.	Methionine synthase I (cobalamin-dependent), methyltransferase domain.	0.889
SEO29103.1	metZ	SAMN04490248_103185	SAMN04490248_10169	5-methyltetrahydrofolate--homocysteine methyltransferase.	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.	0.836

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.818

expected number of edges:

20

PPI enrichment p-value:

0.0113

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019470

4-hydroxyproline catabolic process

2 of 2

2.56

1.03

0.0133

GO:0046653

Tetrahydrofolate metabolic process

3 of 18

1.78

0.95

0.0133

GO:1901606

Alpha-amino acid catabolic process

3 of 28

1.59

0.9

0.0133

GO:0006575

Cellular modified amino acid metabolic process

5 of 102

1.25

0.87

0.0067

GO:0046416

D-amino acid metabolic process

2 of 6

2.08

0.87

0.0231

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008115

Sarcosine oxidase activity

3 of 9

2.08

1.58

0.00085

GO:0016645

Oxidoreductase activity, acting on the CH-NH group of donors

4 of 33

1.64

1.42

0.00074

GO:0016491

Oxidoreductase activity

9 of 515

0.8

0.69

0.00034

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1927

GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and Sarcosine oxidase, delta subunit family

4 of 24

1.78

1.79

0.00013

CL:1922

Mixed, incl. GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1, and NADH:flavin oxidoreductase / NADH oxidase family

5 of 50

1.56

1.63

0.00011

CL:1929

FAD dependent oxidoreductase central domain, and Sarcosine oxidase activity

3 of 18

1.78

1.3

0.0022

CL:1699

Mixed, incl. Carbon metabolism, and Oxidoreductase activity, acting on the CH-NH group of donors

7 of 181

1.15

0.00011

CL:5479

Mixed, incl. Alkylhydroperoxidase AhpD core, and EF-hand, calcium binding motif

2 of 6

2.08

0.92

0.0187

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00472

D-Arginine and D-ornithine metabolism

2 of 3

2.39

1.17

0.0071

map00330

Arginine and proline metabolism

3 of 57

1.28

0.73

0.0203

map01100

Metabolic pathways

11 of 1641

0.39

0.31

0.0071

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1255

0.46

0.34

0.0135

GOCC:0005622

Intracellular

11 of 1613

0.39

0.3

0.0135

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07992

Pyridine nucleotide-disulphide oxidoreductase

4 of 16

1.96

1.99

8.26e-05

PF13510

2Fe-2S iron-sulfur cluster binding domain

3 of 7

2.19

1.71

0.00052

PF04324

BFD-like [2Fe-2S] binding domain

2 of 2

2.56

1.27

0.0047

PF08669

Glycine cleavage T-protein C-terminal barrel domain

3 of 19

1.76

1.19

0.0038

PF01571

Aminomethyltransferase folate-binding domain

3 of 18

1.78

1.19

0.0038

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041117

SoxA, A3 domain

5 of 5

2.56

4.02

1.96e-08

IPR041854

BFD-like [2Fe-2S]-binding domain superfamily

4 of 4

2.56

3.17

1.04e-06

IPR036188

FAD/NAD(P)-binding domain superfamily

7 of 80

1.5

2.15

3.98e-07

IPR042204

2Fe-2S iron-sulfur cluster binding domain, N-terminal

3 of 5

2.34

1.91

0.00025

IPR023753

FAD/NAD(P)-binding domain

4 of 24

1.78

1.7

0.00022

(more ...)

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