node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHG84013.1 | SHG84056.1 | SAMN04488116_2634 | SAMN04488116_2636 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SHG84013.1 | fhs | SAMN04488116_2634 | SAMN04488116_1635 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.936 |
SHG84013.1 | folD | SAMN04488116_2634 | SAMN04488116_2925 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.520 |
SHG84013.1 | gcvT | SAMN04488116_2634 | SAMN04488116_3100 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.888 |
SHG84013.1 | glyA | SAMN04488116_2634 | SAMN04488116_0575 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.879 |
SHG84013.1 | purD | SAMN04488116_2634 | SAMN04488116_1916 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.443 |
SHG84013.1 | purH | SAMN04488116_2634 | SAMN04488116_1356 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.860 |
SHG84013.1 | purN | SAMN04488116_2634 | SAMN04488116_1741 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.869 |
SHG84056.1 | SHG84013.1 | SAMN04488116_2636 | SAMN04488116_2634 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.999 |
SHG84056.1 | fhs | SAMN04488116_2636 | SAMN04488116_1635 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.942 |
SHG84056.1 | gcvT | SAMN04488116_2636 | SAMN04488116_3100 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.879 |
SHG84056.1 | glyA | SAMN04488116_2636 | SAMN04488116_0575 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.879 |
fhs | SHG84013.1 | SAMN04488116_1635 | SAMN04488116_2634 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.936 |
fhs | SHG84056.1 | SAMN04488116_1635 | SAMN04488116_2636 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.942 |
fhs | folD | SAMN04488116_1635 | SAMN04488116_2925 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | gcvT | SAMN04488116_1635 | SAMN04488116_3100 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.912 |
fhs | glyA | SAMN04488116_1635 | SAMN04488116_0575 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
fhs | purC | SAMN04488116_1635 | SAMN04488116_1136 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.821 |
fhs | purD | SAMN04488116_1635 | SAMN04488116_1916 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.767 |
fhs | purH | SAMN04488116_1635 | SAMN04488116_1356 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.977 |