node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIS36777.1 | SIS37253.1 | SAMN05421687_10163 | SAMN05421687_101281 | dCMP deaminase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.537 |
SIS36777.1 | SIS39927.1 | SAMN05421687_10163 | SAMN05421687_10287 | dCMP deaminase. | Dihydrofolate reductase. | 0.537 |
SIS36777.1 | SIS43797.1 | SAMN05421687_10163 | SAMN05421687_103289 | dCMP deaminase. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | 0.841 |
SIS36777.1 | tdk | SAMN05421687_10163 | SAMN05421687_102317 | dCMP deaminase. | Thymidine kinase. | 0.884 |
SIS36777.1 | thyA | SAMN05421687_10163 | SAMN05421687_101280 | dCMP deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.897 |
SIS36777.1 | tmk | SAMN05421687_10163 | SAMN05421687_11341 | dCMP deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.888 |
SIS37253.1 | SIS36777.1 | SAMN05421687_101281 | SAMN05421687_10163 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dCMP deaminase. | 0.537 |
SIS37253.1 | folD | SAMN05421687_101281 | SAMN05421687_101152 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.515 |
SIS37253.1 | gcvT | SAMN05421687_101281 | SAMN05421687_101138 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.861 |
SIS37253.1 | glyA | SAMN05421687_101281 | SAMN05421687_102323 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.875 |
SIS37253.1 | tdk | SAMN05421687_101281 | SAMN05421687_102317 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidine kinase. | 0.553 |
SIS37253.1 | thyA | SAMN05421687_101281 | SAMN05421687_101280 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
SIS37253.1 | tmk | SAMN05421687_101281 | SAMN05421687_11341 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.533 |
SIS37814.1 | folD | SAMN05421687_101458 | SAMN05421687_101152 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.794 |
SIS37814.1 | thyA | SAMN05421687_101458 | SAMN05421687_101280 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.855 |
SIS39927.1 | SIS36777.1 | SAMN05421687_10287 | SAMN05421687_10163 | Dihydrofolate reductase. | dCMP deaminase. | 0.537 |
SIS39927.1 | folD | SAMN05421687_10287 | SAMN05421687_101152 | Dihydrofolate reductase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.514 |
SIS39927.1 | gcvT | SAMN05421687_10287 | SAMN05421687_101138 | Dihydrofolate reductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.490 |
SIS39927.1 | glyA | SAMN05421687_10287 | SAMN05421687_102323 | Dihydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.532 |
SIS39927.1 | tdk | SAMN05421687_10287 | SAMN05421687_102317 | Dihydrofolate reductase. | Thymidine kinase. | 0.553 |