Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
treFTrehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. (550 aa)    
Predicted Functional Partners:
otsB
Trehalose phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
 
 0.988
treC
Trehalose-6-phosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.957
AKL36523.1
Malto-oligosyltrehalose trehalohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.945
AKL35977.1
Glycosidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.906
treA
Trehalase; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family.
  
  
 
0.905
aglB
6-phospho-alpha-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
AKL35519.1
6-phospho-alpha-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
otsA
Trehalose-6-phosphate synthase; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family.
 
  
 0.711
AKL33943.1
GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.586
galM
Galactose-1-epimerase; Converts alpha-aldose to the beta-anomer.
  
 
  0.567
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.