STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nikRNickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (138 aa)    
Predicted Functional Partners:
nikD
Nickel ABC transporter ATP-binding protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.929
nikE
Nickel ABC transporter ATP-binding protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.921
nikC
Nickel transporter permease NikC; With NikABDE is involved in nickel transport into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.901
AKL33982.1
Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.817
AKL33981.1
Nickel transporter permease NikB; With NikACDE is involved in nickel transport into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.802
mntR
Transcriptional regulator that represses the manganese transporter MntH when manganese is present; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.630
cueR
Transcriptional regulator; Activator of copper-responsive regulon genes; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.612
rcnR
Transcriptional repressor rcnR; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.479
zntR
Zinc-responsive transcriptional regulator; Mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.474
AKL34807.1
Hydrogenase nickel incorporation protein HypB; GTP hydrolase involved in nickel liganding into hydrogenases; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.460
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.