Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nikRNickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (138 aa)    
Predicted Functional Partners:
nikD
Nickel ABC transporter ATP-binding protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.932
nikE
Nickel ABC transporter ATP-binding protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.907
nikC
Nickel transporter permease NikC; With NikABDE is involved in nickel transport into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.888
AKL33982.1
Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.847
AKL33981.1
Nickel transporter permease NikB; With NikACDE is involved in nickel transport into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.809
mntR
Transcriptional regulator that represses the manganese transporter MntH when manganese is present; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.651
zntR
Zinc-responsive transcriptional regulator; Mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.560
rcnR
Transcriptional repressor rcnR; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.555
cueR
Transcriptional regulator; Activator of copper-responsive regulon genes; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.554
birA
biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
     
 0.536
Your Current Organism:
Klebsiella oxytoca
NCBI taxonomy Id: 571
Other names: ATCC 13182, Bacillus oxytocus perniciosus, CCUG 15717, CIP 103434, DSM 5175, IAM 14201, K. oxytoca, Klebsiella sp. CECRI-24/07, Klebsiella sp. MN9SED2, LMG 3055, LMG:3055, NBRC 102593, NBRC 105695, NCTC 13727, strain 479-2
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