| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKL34160.1 | AKL38894.1 | AB185_09715 | AB185_24110 | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
| AKL34160.1 | cmk | AB185_09715 | AB185_26455 | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.907 |
| AKL34160.1 | mazG | AB185_09715 | AB185_12810 | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.922 |
| AKL34160.1 | pyrG | AB185_09715 | AB185_12815 | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.904 |
| AKL34160.1 | thyA | AB185_09715 | AB185_12345 | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| AKL38894.1 | AKL34160.1 | AB185_24110 | AB185_09715 | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.902 |
| AKL38894.1 | cmk | AB185_24110 | AB185_26455 | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
| AKL38894.1 | mazG | AB185_24110 | AB185_12810 | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.922 |
| AKL38894.1 | pyrG | AB185_24110 | AB185_12815 | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.902 |
| AKL38957.1 | adk | AB185_31300 | AB185_29225 | Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.925 |
| AKL38957.1 | cmk | AB185_31300 | AB185_26455 | Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.431 |
| AKL38957.1 | mazG | AB185_31300 | AB185_12810 | Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.923 |
| adk | AKL38957.1 | AB185_29225 | AB185_31300 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.925 |
| adk | cmk | AB185_29225 | AB185_26455 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.583 |
| adk | mazG | AB185_29225 | AB185_12810 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| adk | pyrG | AB185_29225 | AB185_12815 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.515 |
| adk | thyA | AB185_29225 | AB185_12345 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.454 |
| cmk | AKL34160.1 | AB185_26455 | AB185_09715 | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Septum formation inhibitor Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.907 |
| cmk | AKL38894.1 | AB185_26455 | AB185_24110 | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
| cmk | AKL38957.1 | AB185_26455 | AB185_31300 | Cytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.431 |
