| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKL35019.1 | rpoE | AB185_14440 | AB185_14425 | SoxR reducing system protein RseC; Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | 0.762 |
| AKL35019.1 | rseA | AB185_14440 | AB185_14430 | SoxR reducing system protein RseC; Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method: Protein Homology. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.960 |
| AKL35019.1 | rseB | AB185_14440 | AB185_14435 | SoxR reducing system protein RseC; Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anti-sigma E factor; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| AKL38756.1 | rseA | AB185_09875 | AB185_14430 | Clp protease ClpP; Derived by automated computational analysis using gene prediction method: Protein Homology. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.837 |
| degP | rseA | AB185_31040 | AB185_14430 | Serine endoprotease; Protease Do; required at high temperature; degrades damaged proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.864 |
| degP | rseB | AB185_31040 | AB185_14435 | Serine endoprotease; Protease Do; required at high temperature; degrades damaged proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | Anti-sigma E factor; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.432 |
| degQ | degS_2 | AB185_09845 | AB185_09840 | Serine endoprotease DegQ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | Serine endoprotease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.623 |
| degQ | rseA | AB185_09845 | AB185_14430 | Serine endoprotease DegQ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.828 |
| degQ | rseB | AB185_09845 | AB185_14435 | Serine endoprotease DegQ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | Anti-sigma E factor; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.412 |
| degS_2 | degQ | AB185_09840 | AB185_09845 | Serine endoprotease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine endoprotease DegQ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | 0.623 |
| degS_2 | rseA | AB185_09840 | AB185_14430 | Serine endoprotease; Derived by automated computational analysis using gene prediction method: Protein Homology. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.970 |
| degS_2 | rseB | AB185_09840 | AB185_14435 | Serine endoprotease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anti-sigma E factor; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.431 |
| fecI_2 | rseA | AB185_24530 | AB185_14430 | RNA polymerase sigma factor FecI; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.848 |
| rpoE | AKL35019.1 | AB185_14425 | AB185_14440 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | SoxR reducing system protein RseC; Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.762 |
| rpoE | rseA | AB185_14425 | AB185_14430 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | 0.997 |
| rpoE | rseB | AB185_14425 | AB185_14435 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | Anti-sigma E factor; Periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| rseA | AKL35019.1 | AB185_14430 | AB185_14440 | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | SoxR reducing system protein RseC; Involved in the reduction of the SoxR iron-sulfur cluster; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.960 |
| rseA | AKL38756.1 | AB185_14430 | AB185_09875 | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | Clp protease ClpP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.837 |
| rseA | degP | AB185_14430 | AB185_31040 | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | Serine endoprotease; Protease Do; required at high temperature; degrades damaged proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | 0.864 |
| rseA | degQ | AB185_14430 | AB185_09845 | anti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] | Serine endoprotease DegQ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S1C family. | 0.828 |
