| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKL35222.1 | cvpA | AB185_15550 | AB185_15560 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.696 |
| AKL35222.1 | dedD | AB185_15550 | AB185_15555 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | 0.918 |
| AKL35222.1 | purF | AB185_15550 | AB185_15565 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.672 |
| cvpA | AKL35222.1 | AB185_15560 | AB185_15550 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.696 |
| cvpA | dedD | AB185_15560 | AB185_15555 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | 0.761 |
| cvpA | holC | AB185_15560 | AB185_33245 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.708 |
| cvpA | purC | AB185_15560 | AB185_15000 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
| cvpA | purE | AB185_15560 | AB185_29020 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.848 |
| cvpA | purF | AB185_15560 | AB185_15565 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.984 |
| cvpA | purL | AB185_15560 | AB185_14505 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.927 |
| cvpA | purM | AB185_15560 | AB185_14935 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylaminoimidazole synthetase; Catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.904 |
| cvpA | purN | AB185_15560 | AB185_14930 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.675 |
| cvpA | zapA | AB185_15560 | AB185_11610 | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.686 |
| dedD | AKL35222.1 | AB185_15555 | AB185_15550 | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.918 |
| dedD | cvpA | AB185_15555 | AB185_15560 | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.761 |
| dedD | holC | AB185_15555 | AB185_33245 | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.411 |
| dedD | purF | AB185_15555 | AB185_15565 | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.691 |
| holC | cvpA | AB185_33245 | AB185_15560 | DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.708 |
| holC | dedD | AB185_33245 | AB185_15555 | DNA polymerase III subunit chi; Binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein DedD; Non-essential cell division protein that could be required for efficient cell constriction. | 0.411 |
| purC | cvpA | AB185_15000 | AB185_15560 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein required for colicin V production; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
